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(Stroke. 2000;31:1294.)
© 2000 American Heart Association, Inc.

Original Contributions

Ischemic Heart Disease in Black South African Stroke Patients

J. Joubert, MD; C. A. McLean, MD; C. M. Reid, PhD; D. Davel, MD; W. Pilloy, MD; R. Delport, PhD; L. Steyn, MSc A. R. P. Walker, MD

From the Department of Neurology, Royal Melbourne Hospital (J.J.), and Department of Pathology, University of Melbourne (C.A.M.), Parkville, Victoria, Australia; and The Baker Medical Research Institute (C.M.R.); Department of Pathology, New Academic Hospital (D.D.); Department of Nuclear Medicine, Medical University of Southern Africa (W.P.); Department of Chemical Pathology, University of Pretoria (R.D.); Vista University (L.S.); and the South African Institute of Medical Research (A.R.P.W.), South Africa.

Correspondence to Dr Jacques Joubert, Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria, Australia 3050. E-mail joubert{at}hotkey.net.au

Background and Purpose—Stroke patients in western countries frequently have coronary artery disease (CAD). In black Africans, CAD has been reported as being rare in both stroke patients and the general population. In this study, an attempt has been made to determine the prevalence of CAD in a black South African stroke population.

Methods—The prevalence of CAD was determined by indicators identified through a series of 5 observational studies in black patients diagnosed with stroke. CAD indicators included (1) bedside diagnosis in 741 patients; (2) resting ECG in 555 consecutively admitted patients; (3) a combination of clinical examination, cardiac ultrasound, radionuclide scintigraphy, and multigated blood pool studies in 102 consecutively admitted patients; (4) thallium scintigraphy in 60 patients; and (5) necropsy in 23 patients.

Results—On bedside questioning, only 0.7% complained of previous angina. There was no history given of myocardial infarction (MI), but documentation of this was found in the clinical notes of 0.7% of the patients. In the resting ECG study, evidence of myocardial ischemia was present in 14.6% and MI in 2.1%. In the combined study, cardiac ischemia was documented on ECG in 12.7% of patients and evidence of previous MI in 5.8%. Cardiac scintigraphic studies revealed changes of myocardial ischemia in 31.7% and MI in 13.3% of the 60 patients studied. Four (17.4%) of 23 patients in the necropsy study had histological evidence of previous MI, and 50% of all patients had evidence of >50% atherosclerotic stenosis in 1, 2, or 3 coronary arteries.

Conclusions—The prevalence of CAD in black African stroke patients is significantly higher than has been documented in the general nonstroke black population as well as in stroke patients. Black stroke patients may have a risk for CAD similar to that of their white counterparts.

Key Words: blacks • cerebrovascular disorders • coronary artery disease • South Africa

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