(Stroke. 2000;31:1628.)
© 2000 American Heart Association, Inc.
Original Contributions |
Genetic Variants of Platelet Glycoprotein Receptors and Risk of Stroke in Young Women
From the Departments of Medicine (A.P.R, B.M.P., D.S.S.), Epidemiology (S.M.S, W.T.L., B.M.P., D.S.S.), Neurology (W.T.L.), and Cardiovascular Health Research Unit (A.P.R., S.M.S, R.M.P., B.M.P., D.S.S.), University of Washington, Seattle; Department of Pathology, PSG Institute of Medical Sciences and Research, Tamilnadu, India (P.N.K.); Fred Hutchinson Cancer Research Center, Seattle, Wash (S.M.S); and the Hemostasis and Thrombosis Research Center and Department of Clinical Epidemiology, University Hospital Leiden (Netherlands) (F.R.R.).
Correspondence to Alexander P. Reiner, MD, University of Washington, Box 359756, Seattle, WA 98195-9756. E-mail apreiner{at}u.washington.edu
Background and Purpose—A number of studies have examined the relationship between genetic platelet glycoprotein variants and early-onset atherothrombotic disease, particularly acute myocardial infarction. Data on the association of these genetic susceptibility markers with ischemic stroke are more limited, and their role in hemorrhagic stroke has not been previously examined.
Methods—We performed genotype analysis for 5 common diallelic platelet glycoprotein polymorphisms in a population-based study of 78 white women aged <45 years with arterial stroke (36 ischemic cases and 42 hemorrhagic cases) and 346 demographically similar control subjects.
Results—The 807T variant of glycoprotein Ia was
associated with a 2-fold increased risk of ischemic stroke
(age-adjusted odds ratio [OR]=2.24; 95% CI=0.99 to 5.06). The
Met145 allele of glycoprotein Ib
was
associated with a trend toward an increased risk of ischemic
stroke that was more pronounced in the homozygous state (OR=10.36), but
the CI is extremely wide because of the small numbers of subjects (95%
CI=1.43 to 79.34). Homozygosity for the Ser843 allele
of the glycoprotein IIb was associated with an 
5-fold
increased risk of ischemic stroke among subgroups of women who
carried a diagnosis of hypertension or diabetes (OR=4.51; 95% CI=1.01
to 20.13) or had elevated plasma homocysteine levels (OR=5.94; 95%
CI=1.53 to 23.05). The genotype distributions for all 5
platelet glycoprotein polymorphisms were similar
among hemorrhagic stroke cases and controls.
Conclusions—Several inherited platelet glycoprotein variants may be associated with an increased risk of ischemic stroke in young women. These associations seemed to be confined to women with other cardiovascular risk factors. Additional studies involving larger numbers of subjects are needed to confirm these preliminary findings.
Key Words: platelets • polymorphism • stroke, hemorrhagic • stroke, ischemic
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