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(Stroke. 2000;31:2103.)
© 2000 American Heart Association, Inc.

Original Contributions

₁-Antichymotrypsin Gene Polymorphism in Patients With Stroke

Nicolás Vila, MD; Victor Obach, MD; Marian Revilla, MD; Rafael Oliva, MD Angel Chamorro, MD

From Neurology (N.V., V.O., M.R., A.C.) and Genetic (R.O.) Services, Hospital Clinic, Barcelona, Spain.

Correspondence to Angel Chamorro, MD, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. E-mail chamorro{at}medicina.ub.es

Background and Purpose—A role for proteolytic enzymes has been suggested in the pathogenesis of stroke. In a search for new genetic factors, we investigated the gene polymorphism of the serine protease inhibitor ₁-antichymotrypsin (ACT) in patients with stroke.

Methods—Two hundred twenty patients with acute ischemic stroke (n=182) and primary intracerebral hemorrhage (n=38) and 70 control subjects without clinical cerebrovascular disease were genotyped for the ACT polymorphism.

Results—The ACT-TT genotype was more frequent in patients with primary intracerebral hemorrhage than in patients with ischemic stroke (31.6% versus16.4%, P<0.05) or in control subjects (21.4%, P=0.1). After adjusting for age, gender, and vascular risk factors, the ACT-TT genotype was associated with primary intracerebral hemorrhage, with an OR of 2.3 (95% CI 1.0 to 5.2) compared with ischemic stroke and an OR of 1.8 (95% CI 0.85 to 9.65) compared with controls.

Conclusions—Pending confirmation in a larger study, our results suggest that the ACT-TT genotype might be a risk factor for primary cerebral hemorrhage.

Key Words: ₁-antichymotrypsin • cerebral hemorrhage • genetics • polymorphism • stroke, ischemic

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