This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jørgensen, L. Articles by Jacobsen, B. K. Search for Related Content PubMed PubMed Citation Articles by Jørgensen, L. Articles by Jacobsen, B. K. Pubmed/NCBI databases Medline Plus Health Information Stroke Related Collections Acute Stroke Syndromes Rehabilitation, Stroke Risk Factors for Stroke

(Stroke. 2001;32:47.)
© 2001 American Heart Association, Inc.

Original Contributions

Bone Mineral Density in Acute Stroke Patients

Low Bone Mineral Density May Predict First Stroke in Women

Lone Jørgensen, MSc; Torgeir Engstad, MD Bjarne K. Jacobsen, PhD

From the Institute of Community Medicine, University of Tromsø, Norway.

Correspondence to Lone Jørgensen, Institute of Community Medicine, University of Tromsø, N-9037 Tromsø, Norway. E-mail Lone.Jorgensen{at}hitos.no

Background and Purpose—Osteoporosis and stroke share several risk factors, including age, smoking, low physical activity, and hypertension. Thus, low bone mineral density (BMD) and high stroke risk may be related. We examined the relationship between BMD and acute stroke in noninstitutionalized men and women aged 60 years.

Methods—Sixty-three stroke patients (33 women and 30 men) and 188 control subjects from the general population were included. BMD was measured by using dual-energy x-ray absorptiometry at both proximal femurs. The measurements of the stroke patients were performed 6 days after the onset of stroke.

Results—The BMD at the femoral neck in the female stroke patients was 8% lower than in the control subjects (P=0.007). In men, no difference in BMD between the stroke patients and their controls was found. Women with BMD values in the lowest quartile had a higher risk of stroke than women with BMD values in the highest quartile (OR 4.8), and the probability value for linear trend over the quartiles was statistically significant (P=0.003). The OR for stroke increased 1.9 per SD (0.13 g/cm²) reduction in BMD, and the association between low BMD and stroke in women remained significant when the analysis was adjusted for potential confounders.

Conclusions—Female, but not male, stroke patients have lower BMD than population controls. Low BMD may predict stroke in women.

Key Words: bone mineral density • osteoporosis • risk factors • stroke, acute

This article has been cited by other articles:

				L. D. Lisabeth, A. S. Beiser, D. L. Brown, J. M. Murabito, M. Kelly-Hayes, and P. A. Wolf Age at Natural Menopause and Risk of Ischemic Stroke: The Framingham Heart Study Stroke, April 1, 2009; 40(4): 1044 - 1049. [Abstract] [Full Text] [PDF]

				K. Tsuda Low Vitamin D Levels and Bone Mineral Density in Stroke Stroke, February 1, 2009; 40(2): e36 - e36. [Full Text] [PDF]

				S. Pilz, H. Dobnig, A. Tomaschitz, J. E. Fischer, B. Wellnitz, U. Seelhorst, B. O. Boehm, and W. Marz Response to Letters by Lee and Greenfield, and Tsuda Stroke, February 1, 2009; 40(2): e37 - e38. [Full Text] [PDF]

				R. L. Gardner, F. Harris, E. Vittinghoff, and S. R. Cummings The Risk of Fracture Following Hospitalization in Older Women and Men Arch Intern Med, August 11, 2008; 168(15): 1671 - 1677. [Abstract] [Full Text] [PDF]

				J. Reddy, J. P. Bilezikian, S. J. Smith, and L. Mosca Reduced Bone Mineral Density Is Associated with Breast Arterial Calcification J. Clin. Endocrinol. Metab., January 1, 2008; 93(1): 208 - 211. [Abstract] [Full Text] [PDF]

				N. J. Bainbridge, M. W. J. Davie, and M. J. Haddaway Bone loss after stroke over 52 weeks at os calcis: influence of sex, mobility and relation to bone density at other sites Age Ageing, March 1, 2006; 35(2): 127 - 132. [Abstract] [Full Text] [PDF]

				K. Tsuda, M. E. Mussolino, J. H. Madans, and R.F. Gillum Bone Mineral Density, Blood Pressure, and Stroke in Elderly Women * Response Stroke, November 1, 2003; 34 (11): e210 - e211. [Full Text] [PDF]

				A. Taguchi, Y. Suei, M. Sanada, Y. Higashi, M. Ohtsuka, T. Nakamoto, M. Tsuda, K. Ohama, and K. Tanimoto Detection of Vascular Disease Risk in Women by Panoramic Radiography Journal of Dental Research, October 1, 2003; 82(10): 838 - 843. [Abstract] [Full Text] [PDF]

				K.-i. Hirose, H. Tomiyama, R. Okazaki, T. Arai, Y. Koji, G. Zaydun, S. Hori, and A. Yamashina Increased Pulse Wave Velocity Associated with Reduced Calcaneal Quantitative Osteo-sono Index: Possible Relationship Between Atherosclerosis and Osteopenia J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2573 - 2578. [Abstract] [Full Text] [PDF]

				M. E. Mussolino, J. H. Madans, and R.F. Gillum Bone Mineral Density and Stroke Stroke, May 1, 2003; 34 (5): e20 - e22. [Abstract] [Full Text] [PDF]

				D H. Jones, Y-Y Kong, and J M Penninger Role of RANKL and RANK in bone loss and arthritis Ann Rheum Dis, November 1, 2002; 61(90002): ii32 - 39. [Abstract] [Full Text] [PDF]

				K. E.S. Poole, J. Reeve, and E. A. Warburton Falls, Fractures, and Osteoporosis After Stroke: Time to Think About Protection? Stroke, May 1, 2002; 33(5): 1432 - 1436. [Abstract] [Full Text] [PDF]

				M. E. Mussolino, R. F. Gillum, J. H. Madans, L. Jorgensen, T. Engstad, and B. K. Jacobsen Bone Mineral Density and Stroke Risk Response Stroke, December 1, 2001; 32(12): 2956 - 2957. [Full Text] [PDF]