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(Stroke. 2001;32:2507.)
© 2001 American Heart Association, Inc.

Original Contributions

Mitochondrial Disease and Stroke

E. Martínez-Fernández, MD; A. Gil-Peralta, PhD; R. García-Lozano, PhD; I. Chinchón, PhD; I. Aguilera, PhD; O. Fernández-López, MD; J. Arenas, PhD; Y. Campos, PhD J. Bautista, PhD

From the Stroke and Neuromuscular Units, Departments of Neurology (E.M.-F., A.G.-P., J.B.), Immunology (R.G.-L., I.A., O.F.-L.), and Pathology (I.C.), Hospital Universitario Virgen del Rocío, Sevilla, Spain, and the Research Center (J.A., Y.C.). Hospital Doce de Octubre, Madrid, Spain.

Correspondence to Dr Eva Martínez-Fernández, S. Neurología, H.U. Virgen del Rocío, Av. Manuel Siurot s/n, 41013 Sevilla, Spain. E-mail med010426{at}nacom.es

Background and Purpose—— It is well known that some mitochondrial disorders are responsible for ischemic cerebral infarction in young patients. Our purpose was to determine, in this prospective ongoing study, whether ischemic stroke is the only manifestation of a mitochondrial disorder in young patients.

Methods—— Patients aged 50 years, admitted to the Stroke Unit from January 1999 to May 2000 with a diagnosis of ischemic stroke of unknown origin, were included in the study. All of them had full biochemical and hematologic tests, neuroimaging studies, transesophageal echocardiography, and extracranial and transcranial Doppler sonography. Patent foramen ovale was ruled out. Lactic acid concentrations were measured after anaerobic exercise of the forearm, and a morphological, biochemical, and molecular study after biceps muscle biopsy was performed.

Results—— Of the 18 patients so far included, 3 (17%) presented lactic acid hyperproduction after physical exercise, and 6 (33%) showed deficit of the mitochondrial respiratory chain complexes. The molecular analyses have confirmed mitochondrial mutations at base pairs 3243 (characteristic of mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes [MELAS]), 4216, and 15 928.

Conclusions—— These results suggest that ischemic stroke may be the only manifestation or the initial manifestation of a mitochondrial disorder.

Key Words: cerebral infarction • mitochondrial myopathies • stroke • young adults

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