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(Stroke. 2001;32:413.)
© 2001 American Heart Association, Inc.
Original Contributions |
Stroke Severity Determines Body Temperature in Acute Stroke
From the Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Correspondence to Gudrun Boysen, Professor of Neurology, Department of Neurology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. E-mail gb01{at}bbh.hosp.dk
Background and Purpose—Several studies have claimed that temperature on admission is of prognostic significance in acute stroke. Experimental studies showing that hyperthermia increases infarct size have lent credibility to this assumption. The aim of the present study was to test the hypothesis that initial body temperature is of importance for stroke outcome.
Methods—This
prospective study included 725 consecutive patients, 584 with cerebral
infarcts and 141 with intracerebral
hemorrhages, admitted to an acute stroke unit within 6 hours of
stroke onset. Time of stroke onset and time of admission were
recorded. Body temperature was measured on admission and every 2
hours during the first 24 hours. Patients were divided into 2 groups on
the basis of stroke severity on admission: Scandinavian Stroke Scale
Score (SSS) 
25 was defined as major stroke, and SSS >25 was defined
as mild to moderate stroke.
Results—On admission, mean body temperature was normal. In the major stroke patients, body temperature started to rise 4 to 6 hours after stroke onset. At 10 to 12 hours after stroke onset, increased body temperature was found to be related to poor outcome. In mild to moderate stroke, there was no significant rise in temperature. Initial temperature >37.5°C was not related to stroke severity or stroke outcome.
Conclusions—In major stroke, a significant rise in temperature occurred hours after stroke onset. Severe infarcts and intracerebral hemorrhages caused temperature to rise, whereas initially increased temperature had no influence on stroke severity. Elevated body temperature on admission within 6 hours of stroke onset had no prognostic influence on stroke outcome at 3 months.
Key Words: body temperature • cerebral infarction • hyperthermia • intracerebral hemorrhage • outcome
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