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(Stroke. 2001;32:1825.)
© 2001 American Heart Association, Inc.

Original Contributions

High-Resolution Turbo Magnetic Resonance Angiography for Diagnosis of Moyamoya Disease

Ichiro Yamada, MD; Tsuneaki Nakagawa, MD; Yoshiharu Matsushima, MD Hitoshi Shibuya, MD

From the Departments of Radiology (I.Y., T.N., H.S.) and Neurosurgery (Y.M.), Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Correspondence to Ichiro Yamada, MD, Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. E-mail yamada.crad{at}med.tmd.ac.jp

Background and Purpose—— High-resolution turbo MR angiography with zero-filling interpolation (ZFI) technique is a new vascular imaging method with reduced scan time. The purpose of the present study was to evaluate high-resolution turbo MR angiography for the diagnosis and assessment of moyamoya disease.

Methods—— Forty-six patients suspected of having moyamoya disease were examined with high-resolution turbo MR angiography with the ZFI technique, MRI, and conventional angiography. Moyamoya disease was diagnosed in 42 of these patients. Blind, separate interpretation of the images was performed.

Results—— High-resolution turbo MR angiography and MRI accurately evaluated 349 (95%) and 325 (88%) of 368 arteries, respectively, but the degree of stenosis was overestimated in the other arteries. MR angiography and MRI depicted basal cerebral moyamoya vessels in 82 (98%) and 82 (98%) of 84 hemispheres, respectively. MR angiography also depicted leptomeningeal and transdural collateral vessels in 51 (100%) of 51 hemispheres and in 38 (88%) of 43 hemispheres, respectively. The sensitivity and specificity of high-resolution turbo MR angiography for the diagnosis of moyamoya disease were 98% and 100%, respectively.

Conclusions—— High-resolution turbo MR angiography in reduced scan time is highly accurate in the assessment of both steno-occlusive lesions and collateral vessels in moyamoya disease, thus providing a highly accurate (98%) diagnosis and assessment of moyamoya disease.

Key Words: angiography • angiography, magnetic resonance • magnetic resonance imaging • moyamoya disease

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