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(Stroke. 2002;33:913.)
© 2002 American Heart Association, Inc.

Original Contributions

Stroke Risk Factor Profiles in African American Women

An Interim Report From the African-American Antiplatelet Stroke Prevention Study

Bradford B. Worrall, MD, MSc; Karen C. Johnston, MD, MSc; Gail Kongable, MSN, FNP-C; Elena Hung, MS; DeJuran Richardson, PhD Philip B. Gorelick, MD, MPH for the AAASPS Investigators

From the Departments of Neurology (B.B.W., K.C.J., G.K.) and Health Evaluation Sciences (B.B.W., K.C.J.), University of Virginia, Charlottesville; Departments of Preventive Medicine (E.H., D.R.) and Neurology (P.B.G), Rush Medical College, Chicago, Ill; and Department of Mathematics, Lake Forest College (D.R.), Lake Forest, Ill. Drs Worrall and Johnston contributed equally to this work.

Correspondence to Karen C. Johnston, MD, MSc, University of Virginia Health System, Department of Neurology 800394, Charlottesville, VA 22908. E-mail kj4v{at}virginia.edu

Background and Purpose— If sex differences in stroke risk factor profiles exist among African Americans in the United States, prevention strategies will need to reflect those differences. African Americans and women have been underrepresented in stroke prevention studies. The purpose of this study was to determine whether medical and lifestyle factors differ among women and men who have enrolled in the African-American Antiplatelet Stroke Prevention Study (AAASPS).

Methods— We performed a planned exploratory analysis of differences in baseline characteristics and risk factors between women and men enrolled in AAASPS, a double-blind, randomized, multicenter, controlled trial. Frequencies of vascular risk factors and related conditions, medical therapies, stroke subtypes, and vascular territories were compared between women and men by 1-way ANOVA and Fisher’s exact test where appropriate.

Results— A total of 1087 African American patients (574 women, 513 men) enrolled between December 1995 and June 1999. Women had higher rates of hypertension, diabetes, family history of stroke, and no reported leisure exercise. Men had higher rates of smoking and heavy alcohol use. Few differences were noted in proportions of stroke subtype or proportions receiving preventive therapy.

Conclusions— AAASPS represents the largest enrollment of African American women in a recurrent stroke prevention study. Our data suggest that African American women in a clinical trial differ from men in the frequency of key vascular risk factors. Although limited, these data provide an important first characterization of sex differences in African Americans with stroke.

Key Words: cerebrovascular disorders • ischemia • racial differences • risk factors • women

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