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(Stroke. 2002;33:1551.)
© 2002 American Heart Association, Inc.

Original Contributions

Thrombolysis-Related Hemorrhagic Infarction

A Marker of Early Reperfusion, Reduced Infarct Size, and Improved Outcome in Patients With Proximal Middle Cerebral Artery Occlusion

Carlos A. Molina, MD; José Alvarez-Sabín, MD; Joan Montaner, MD; Sonia Abilleira, MD; Juan F. Arenillas, MD; Pilar Coscojuela, MD; Francisco Romero, MD Agusti Codina, MD

From the Cerebrovascular Unit, Departments of Neurology (C.A.M., J.A.-S., J.M., S.A., J.F.A., A.C.) and Neuroradiology (P.C., F.R.), Hospital Vall d‘Hebrón, Barcelona, Spain.

Correspondence to Carlos A. Molina, MD, Cerebrovascular Unit, Department of Neurology, Hospital Vall d’Hebrón, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain. E-mail carmolcate{at}demasiado.com

Background and Purpose— The role of early and delayed recanalization after thrombolysis in the development of hemorrhagic transformation (HT) subtypes remains uncertain. We sought to explore the association between the timing of recanalization and HT risk in patients with proximal middle cerebral artery (MCA) occlusion treated with intravenous recombinant tissue plasminogen activator (rtPA) <3 hours of stroke onset and to investigate the relationship between HT subtypes, infarct volume, and outcome.

Methods— Thirty-two patients with acute stroke caused by proximal MCA occlusion treated with rtPA <3 hours of symptom onset were prospectively studied. Serial transcranial Doppler examinations were performed on admission and at 6, 12, 24, and 48 hours. Presence and type of HT were assessed on CT at 36 to 48 hours. Modified Rankin scale was used to assess outcome at 3 months.

Results— Early and delayed recanalization was identified in 17 patients (53.1%) and 8 patients (25%), respectively. HT was detected in 14 patients (43.7%): 4 (12.5%) with hemorrhagic infarction (HI₁), 5 (15.6%) with HI₂, 3 (9.3%) with parenchymal hematoma (PH₁), and 2 (6.8%) with PH₂. Distribution of HT subtypes differed significantly (P=0.025), depending on the time to artery reopening. Eight of 9 (89%), 1 of 5 (20%), and 8 of 18 (44.4%) with HI₁-HI₂, with PH₁-PH₂, and without HT, respectively, recanalized in <6 hours. Delayed recanalization was observed in 1 patient with HI₁-HI₂ (11%), 4 with PH₁-PH₂ (80%), and 3 without HT (16.6%). Neurological improvement was significantly (P<0.001) more frequent in patients with HI₁-HI₂ (88%) than in those without HT (39%). Infarct volume was significantly (P<0.031) lower in patients with HI₁-HI₂ (51.4±42 cm³) than in patients with PH₁-PH₂ (83.8±48 cm³) and those without HT (98.4±84 cm³, P=0.021). The modified Rankin scale score was significantly lower in HI₁-HI₂ compared with PH₁-PH₂ patients (1.9±1.1 versus 4.6±1.2, P<0.001) and with those without HT (1.9±1.1 versus 3.5±2.0, P=0.009.).

Conclusions— Thrombolysis-related HI (HI₁-HI₂) represents a marker of early successful recanalization, which leads to a reduced infarct size and improved clinical outcome.

Key Words: hemorrhage • reperfusion • thrombolysis • ultrasonography

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