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(Stroke. 2002;33:1999.)
© 2002 American Heart Association, Inc.

Original Contributions

Neuropsychological Predictors of Incident Dementia in Patients With Vascular Cognitive Impairment, Without Dementia

Janet L. Ingles, PhD; Carolyn Wentzel, PhD; John D. Fisk, PhD Kenneth Rockwood, MD

From the School of Human Communication Disorders (J.L.I.) and the Departments of Geriatric Medicine Research (C.W., K.R.) and Psychiatry (J.D.F.), Dalhousie University, Halifax, Nova Scotia, Canada.

Correspondence to Kenneth Rockwood, MD, Queen Elizabeth II Health Sciences Center, Geriatric Medicine Research Unit, Suite 1421, 5955 Veterans’ Memorial Lane, Halifax, Nova Scotia B3H 2E1, Canada. E-mail Kenneth.Rockwood{at}Dal.Ca

Background— Vascular cognitive impairment that does not fulfill dementia criteria (ie, vascular cognitive impairment, no dementia [CIND]) is common. Although progression to dementia is frequent, little is known about factors that predict progression. We examined whether performance on neuropsychological tests administered at baseline could predict incident cases of dementia in patients with vascular CIND after 5 years.

Summary of Report— The Canadian Study of Health and Aging is a prospective, cohort study of 10 263 randomly selected persons aged 65 years. Of 149 people diagnosed with vascular CIND, 125 completed a battery of neuropsychological tests at baseline. Follow-up cognitive diagnoses were available for 102 individuals. After 5 years, 45 patients (44%) developed dementia. Low baseline scores on tests of memory and category fluency were associated with incident dementia.

Conclusions— Neuropsychological measures can indicate risk of dementia in patients with vascular CIND. This study did not suggest a prediction-to-progression profile distinct from that seen in Alzheimer disease.

Key Words: cerebrovascular disorders • dementia • neuropsychology

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