This Article Full Text Full Text (PDF) All Versions of this Article: 34/5/1136    most recent 01.STR.0000069161.35736.39v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Srikanth, V. K. Articles by Donnan, G. A. Search for Related Content PubMed PubMed Citation Articles by Srikanth, V. K. Articles by Donnan, G. A. Pubmed/NCBI databases Medline Plus Health Information Stroke Related Collections Behavioral/psychosocial - stroke Behavioral Changes and Stroke

(Stroke. 2003;34:1136.)
© 2003 American Heart Association, Inc.

Original Contributions

Increased Risk of Cognitive Impairment 3 Months After Mild to Moderate First-Ever Stroke

A Community-Based Prospective Study of Nonaphasic English-Speaking Survivors

Velandai K. Srikanth, PhD; Amanda G. Thrift, PhD; Michael M. Saling, PhD; Jacqueline F.I. Anderson, BSc; Helen M. Dewey, PhD; Richard A.L. Macdonell, MD Geoffrey A. Donnan, MD

From the Epidemiology Division, National Stroke Research Institute, Austin & Repatriation Medical Center (V.K.S., A.G.T., H.M.D., R.A.L.M., G.A.D.), and Department of Neuropsychology, University of Melbourne, Parkville (M.M.S., J.F.I.A.), Melbourne, Australia.

Correspondence to Dr Velandai K. Srikanth, Menzies Centre for Population Health Research, 17 Liverpool St, Hobart, Tasmania, Australia. E-mail velandai.srikanth{at}utas.edu.au

Background and Purpose— Results of hospital-based studies indicate a high risk of cognitive impairment 3 months after stroke. There are no comprehensive data on this issue from prospective community-based studies comparing first-ever stroke patients with stroke-free subjects.

Methods— We administered a comprehensive neuropsychological battery to 99 community-based nonaphasic survivors of first-ever stroke at 3 months and 99 age- and sex-matched (1:1) stroke-free individuals. Domain-specific cognitive deficits were identified by blinded neuropsychological consensus.

Methods— Stroke patients were more likely to suffer any cognitive impairment (relative risk [RR], 1.5; 95% CI, 1.1 to 2.1) attributable mainly to a greater risk of single-domain cognitive impairment (RR, 2.8; 95% CI, 1.5 to 5.3) but not multiple-domain cognitive impairment (RR, 1.2; 95% CI, 0.8 to 1.9).

Conclusions— In this community-based study, a first-ever stroke of mild to moderate severity was associated with a significant risk of cognitive impairment at 3 months, even in the absence of clinical aphasia. This was due primarily to an increased risk of solitary deficits rather than generalized deficits.

Key Words: cognition • dementia • epidemiology • stroke

This article has been cited by other articles:

				J. A. Luchsinger, A. M. Brickman, C. Reitz, S. J. Cho, N. Schupf, J. J. Manly, M. X. Tang, S. A. Small, R. Mayeux, C. DeCarli, et al. Subclinical cerebrovascular disease in mild cognitive impairment Neurology, August 11, 2009; 73(6): 450 - 456. [Abstract] [Full Text] [PDF]

				M Hommel, S T Miguel, B Naegele, N Gonnet, and A Jaillard Cognitive determinants of social functioning after a first ever mild to moderate stroke at vocational age J. Neurol. Neurosurg. Psychiatry, August 1, 2009; 80(8): 876 - 880. [Abstract] [Full Text] [PDF]

				N. J. Donovan, D. L. Kendall, S. C. Heaton, S. Kwon, C. A. Velozo, and P. W. Duncan Conceptualizing Functional Cognition in Stroke Neurorehabil Neural Repair, April 1, 2008; 22(2): 122 - 135. [Abstract] [PDF]

				T. Ewert and G. Stucki Validity of the SS-QOL in Germany and in Survivors of Hemorrhagic or Ischemic Stroke Neurorehabil Neural Repair, March 1, 2007; 21(2): 161 - 168. [Abstract] [PDF]

				S. Serrano, J. Domingo, E. Rodriguez-Garcia, M.-D. Castro, and T. del Ser Frequency of Cognitive Impairment Without Dementia in Patients With Stroke: A Two-Year Follow-Up Study Stroke, January 1, 2007; 38(1): 105 - 110. [Abstract] [Full Text] [PDF]

				L. Snaphaan and F.-E. de Leeuw Poststroke Memory Function in Nondemented Patients: A Systematic Review on Frequency and Neuroimaging Correlates Stroke, January 1, 2007; 38(1): 198 - 203. [Abstract] [Full Text] [PDF]

				V. K. Srikanth, S. J. Quinn, G. A. Donnan, M. M. Saling, and A. G. Thrift Long-Term Cognitive Transitions, Rates of Cognitive Change, and Predictors of Incident Dementia in a Population-Based First-Ever Stroke Cohort Stroke, October 1, 2006; 37(10): 2479 - 2483. [Abstract] [Full Text] [PDF]

				V. K. Srikanth, J. F.I. Anderson, G. A. Donnan, M. M. Saling, E. Didus, R. Alpitsis, H. M. Dewey, R. A.L. Macdonell, and A. G. Thrift Progressive dementia after first-ever stroke: A community-based follow-up study Neurology, September 14, 2004; 63(5): 785 - 792. [Abstract] [Full Text] [PDF]