This Article Full Text Full Text (PDF) All Versions of this Article: 34/5/1176    most recent 01.STR.0000069160.05292.41v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Spence, J. D. Articles by Hegele, R. A. Search for Related Content PubMed PubMed Citation Articles by Spence, J. D. Articles by Hegele, R. A. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Medline Plus Health Information Carotid Artery Disease Genetics Home Reference Related Collections Cerebrovascular disease/stroke Lipids Genetics of cardiovascular disease Risk Factors Genetics of Stroke Doppler ultrasound, Transcranial Doppler etc.

(Stroke. 2003;34:1176.)
© 2003 American Heart Association, Inc.

Original Contributions

Lipoprotein Lipase (LPL) Gene Variation and Progression of Carotid Artery Plaque

From the Stroke Prevention and Atherosclerosis Research Centre (J.D.S.) and Blackburn Cardiovascular Genetics Laboratory (M.R.B., R.A.H.), Robarts Research Institute, London, Ontario, Canada.

Correspondence to Dr David Spence, Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Rd, London, Ontario, Canada N6G 2V2. E-mail dspence{at}robarts.ca

Background and Purpose— Coding single nucleotide polymorphisms (cSNPs) in the lipoprotein lipase (LPL) gene have been associated with lipoprotein phenotypes and vascular disease risk. We studied the association between LPL cSNPs and a novel noninvasive measure of disease, namely, cross-sectional carotid plaque area (CPA) on B-mode ultrasound.

Methods— Four hundred fifty-two patients from an atherosclerosis prevention clinic had determinations of baseline and total CPA. Traditional atherosclerosis risk factors were recorded, and the LPL D9N, N291S, and S447X cSNPs were genotyped. Multiple regression analysis was used to identify determinants of CPA.

Results— Minor allele frequencies for LPL D9N, N291S, and S447X were 2.8%, 0.9%, and 4.4%, respectively. There were no significant between-genotype differences in treated fasting lipids. The LPL D9N genotype was a significant predictor of both baseline CPA (P=0.008) and plaque progression from baseline to 1 year later (P=0.001). Heterozygotes for the N9 allele had higher mean baseline CPA and plaque progression than did LPL D9/D9 homozygotes.

Conclusions— LPL D9N genotype may be a determinant of atherosclerosis as estimated by static baseline CPA and by progression of CPA.

Key Words: atherosclerosis • carotid artery plaque • genetics • lipoprotein lipase

This article has been cited by other articles:

				Y. Hu, W. Liu, R. Huang, and X. Zhang A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases J. Lipid Res., September 1, 2006; 47(9): 1908 - 1914. [Abstract] [Full Text] [PDF]

				J. Rip, M. C. Nierman, C. J. Ross, J. W. Jukema, M. R. Hayden, J. J.P. Kastelein, E. S.G. Stroes, and J. A. Kuivenhoven Lipoprotein Lipase S447X: A Naturally Occurring Gain-of-Function Mutation Arterioscler. Thromb. Vasc. Biol., June 1, 2006; 26(6): 1236 - 1245. [Abstract] [Full Text] [PDF]

				R. A Wyman, M. E Mays, P. E McBride, and J. H Stein Ultrasound-detected carotid plaque as a predictor of cardiovascular events Vascular Medicine, May 1, 2006; 11(2): 123 - 130. [Abstract] [PDF]

				R. A. Hegele, K. Z. Al-Shali, A. A. House, A. J.G. Hanley, S. B. Harris, M. Mamakeesick, A. Fenster, B. Zinman, H. Cao, and J. D. Spence Disparate Associations of a Functional Promoter Polymorphism in PCK1 With Carotid Wall Ultrasound Traits Stroke, December 1, 2005; 36(12): 2566 - 2570. [Abstract] [Full Text] [PDF]

				K P Burdon, C D Langefeld, S R Beck, L E Wagenknecht, J J Carr, B I Freedman, D Herrington, and D W Bowden Association of genes of lipid metabolism with measures of subclinical cardiovascular disease in the Diabetes Heart Study J. Med. Genet., September 1, 2005; 42(9): 720 - 724. [Abstract] [Full Text] [PDF]

				J. D. Spence, R. A. Hegele, T. Manolio, E. Boerwinkle, C. O'Donnell, and A. F. Wilson Noninvasive Phenotypes of Atherosclerosis Arterioscler. Thromb. Vasc. Biol., November 1, 2004; 24(11): e188 - e189. [Full Text] [PDF]

				M. E. Brousseau, A. L. Goldkamp, D. Collins, S. Demissie, A. C. Connolly, L. A. Cupples, J. M. Ordovas, H. E. Bloomfield, S. J. Robins, and E. J. Schaefer Polymorphisms in the gene encoding lipoprotein lipase in men with low HDL-C and coronary heart disease: The Veterans Affairs HDL Intervention Trial J. Lipid Res., October 1, 2004; 45(10): 1885 - 1891. [Abstract] [Full Text] [PDF]

				T. A. Manolio, E. Boerwinkle, C. J. O'Donnell, and A. F. Wilson Genetics of Ultrasonographic Carotid Atherosclerosis Arterioscler. Thromb. Vasc. Biol., September 1, 2004; 24(9): 1567 - 1577. [Abstract] [Full Text] [PDF]

				F. Iemolo, A. Martiniuk, D. A. Steinman, and J. D. Spence Sex Differences in Carotid Plaque and Stenosis Stroke, February 1, 2004; 35(2): 477 - 481. [Abstract] [Full Text] [PDF]