This Article Full Text Full Text (PDF) All Versions of this Article: 34/5/e29    most recent 01.STR.0000068784.36838.19v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stapf, C. Articles by Mohr, J.P. Search for Related Content PubMed PubMed Citation Articles by Stapf, C. Articles by Mohr, J.P. Related Collections Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Intracerebral Hemorrhage Aneurysm, AVM, hematoma

(Stroke. 2003;34:e29.)
© 2003 American Heart Association, Inc.

Research Report

The New York Islands AVM Study

Design, Study Progress, and Initial Results

C. Stapf, MD; H. Mast, MD; R.R. Sciacca, EngScD; A. Berenstein, MD; P.K. Nelson, MD; Y.P. Gobin, MD; J. Pile-Spellman, MD J.P. Mohr, MD for the New York Islands AVM Study Collaborators

From the Stroke Center, The Neurological Institute (C.S., H.M., J.P.M.), and Departments of Interventional Neuroradiology (J.P.-S.) and Medicine (R.R.S.), Columbia University College of Physicians and Surgeons; Center for Endovascular Surgery, Beth Israel Medical Center (A.B.); Department of Radiology, New York University Medical Center (P.K.N.); Division of Interventional Neuroradiology, New York Weill Cornell Hospital (Y.P.G.), New York, NY; and Department of Neurology, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany (C.S.).

Correspondence to Christian Stapf, MD, Stroke Center/The Neurological Institute, Columbia University College of Physicians and Surgeons, 710 W 168th St, New York, NY 10032. E-mail cstapf{at}neuro.columbia.edu

Abstract

Background and Purpose— Prospective population-based data on the incidence of brain arteriovenous malformation (AVM) hemorrhage are scarce. We studied lifetime detection rates of brain AVM and incident AVM hemorrhage in a defined population.

Methods— The New York islands (ie, Manhattan Island, Staten Island, and Long Island) comprise a 9 429 541 population according to the 2000 census. Since March 15, 2000, all major New York islands hospitals have prospectively reported data on consecutive patients living in the study area with a diagnosis of brain AVM and whether the patient had suffered AVM hemorrhage. Patients living outside the ZIP code–defined study area were excluded from the study population.

Results— As of June 14, 2002, 284 prospective AVM patients (mean±SD age, 35±18 years; 49% women) were encountered during 21 216 467 person-years of observation, leading to an average annual AVM detection rate of 1.34 per 100 000 person-years (95% CI, 1.18 to 1.49). The incidence of first-ever AVM hemorrhage (n=108; mean age, 31±19 years; 45% women) was 0.51 per 100 000 person-years (95% CI, 0.41 to 0.61). The estimated prevalence of AVM hemorrhage among detected cases (n=144; mean age, 33±19 years; 50% women) was 0.68 per 100 000 (95% CI, 0.57 to 0.79).

Conclusions— Our prospective data, spanning 27 months, suggest stable rates for AVM detection and incident AVM hemorrhage. Approximately half of AVM patients may suffer intracranial hemorrhage.

Key Words: cerebral arteriovenous malformations • epidemiology • hemorrhage

This article has been cited by other articles:

				J van Beijnum, H B van der Worp, H M Schippers, O van Nieuwenhuizen, L J Kappelle, G J E Rinkel, J W B. van der Sprenkel, and C J M Klijn Familial occurrence of brain arteriovenous malformations: a systematic review J. Neurol. Neurosurg. Psychiatry, November 1, 2007; 78(11): 1213 - 1217. [Abstract] [Full Text] [PDF]

				C. Stapf, H. Mast, R. R. Sciacca, J. H. Choi, A. V. Khaw, E. S. Connolly, J. Pile-Spellman, and J. P. Mohr Predictors of hemorrhage in patients with untreated brain arteriovenous malformation Neurology, May 9, 2006; 66(9): 1350 - 1355. [Abstract] [Full Text] [PDF]

				M. Cronqvist, R. Wirestam, B. Ramgren, L. Brandt, B. Romner, O. Nilsson, H. Saveland, S. Holtas, and E.-M. Larsson Endovascular Treatment of Intracerebral Arteriovenous Malformations: Procedural Safety, Complications, and Results Evaluated by MR Imaging, Including Diffusion and Perfusion Imaging AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 162 - 176. [Abstract] [Full Text] [PDF]

				G. Grasso Editorial Comment--Age-Dependent Brain AVM Characteristics: What is the Evidence? Stroke, November 1, 2003; 34(11): 2669 - 2670. [Full Text] [PDF]