This Article Full Text Full Text (PDF) All Versions of this Article: 34/7/1686    most recent 01.STR.0000077256.35566.59v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lee, Y. Z. Articles by Lin, W. Search for Related Content PubMed PubMed Citation Articles by Lee, Y. Z. Articles by Lin, W. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information MRI Scans Stroke Related Collections Imaging Acute Cerebral Hemorrhage Brain Circulation and Metabolism Computerized tomography and Magnetic Resonance Imaging

(Stroke. 2003;34:1686.)
© 2003 American Heart Association, Inc.

Original Contributions

Rapid Perfusion Abnormality Estimation in Acute Stroke With Temporal Correlation Analysis

Yueh Z. Lee, MS; Jin-Moo Lee, MD, PhD; Katie Vo, MD; Chung Y. Hsu, MD, PhD Weili Lin, PhD

From the Departments of Biomedical Engineering (Y.Z.L., W.L.), Radiology (W.L.), and Neurology (W.L.), University of North Carolina, Chapel Hill, and Departments of Neurology (J.-M.L., C.Y.H.) and Radiology (K.V.), Washington University, St Louis, Mo.

Correspondence to Weili Lin, PhD, Department of Radiology, University of North Carolina at Chapel Hill, CB 7515, Chapel Hill, NC 27599-7515. E-mail weili_lin{at}med.unc.edu

Background and Purpose— Determination of the presence or absence of ischemic penumbra through diffusion-perfusion mismatch requires rapid delineation of both abnormalities. Although singular value decomposition–based perfusion parameter estimation has offered valuable insights into the underlying cerebral hemodynamics, the associated postprocessing procedures have limited its widespread use. We explored the utility of a simple technique to define perfusion abnormality in acute stroke patients.

Methods— Twenty acute stroke patients were studied. The MR dynamic contrast approach was used to obtain cerebral blood flow, cerebral blood volume, and mean transit time (MTT). Temporal correlation was used to correlate 4 reference functions—an arterial input function (AIF), a normal tissue function, a lesion function, and a venous output function—with dynamic contrast MR images, and correlation coefficients (CCs) were calculated pixel by pixel. In addition, chronic-state T2-weighted images were coregistered onto the images acquired acutely for assessing the sensitivity and specificity of CC-defined lesion.

Results— Statistically significant differences in cerebral blood flow and MTT were found between CC-defined normal and abnormal tissues with all 4 reference functions used. When the final infarct volume was used as the gold standard, a similar sensitivity between MTT (78%) and AIF (76%) CC-defined lesion was obtained, whereas the specificity was higher for AIF (61%) than that obtained with MTT-defined lesion (52%).

Conclusions— We explored CC maps as a simpler alternative of estimating perfusion abnormality, and results demonstrated the potential clinical utility of a correlation-based technique for estimating brain perfusion status.

Key Words: hemodynamics • magnetic resonance imaging

This article has been cited by other articles:

				P.G. Kranz and J.D. Eastwood Does Diffusion-Weighted Imaging Represent the Ischemic Core? An Evidence-Based Systematic Review AJNR Am. J. Neuroradiol., June 1, 2009; 30(6): 1206 - 1212. [Abstract] [Full Text] [PDF]

				F CHEN, Q LIU, H WANG, Y SUZUKI, N NAGAI, J YU, G MARCHAL, and Y NI Comparing two methods for assessment of perfusion-diffusion mismatch in a rodent model of ischaemic stroke: a pilot study Br. J. Radiol., March 1, 2008; 81(963): 192 - 198. [Abstract] [Full Text] [PDF]