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(Stroke. 2004;35:2276.)
© 2004 American Heart Association, Inc.

Original Contributions

Genome-Wide Linkage in a Large Dutch Consanguineous Family Maps a Locus for Intracranial Aneurysms to Chromosome 2p13

Y.B.W.E.M. Roos, MD PhD; G. Pals, PhD; P.M. Struycken, MD; G.J.E. Rinkel, MD PhD; M. Limburg, MD PhD; J.C. Pronk, PhD; J.S.P. van den Berg, MD PhD; J.A.F.M. Luijten, MD PhD; P.L. Pearson, PhD; M. Vermeulen, MD PhD A. Westerveld, PhD

From the Department of Neurology (Y.B.W.E.M.R., P.M.S., M.V.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; the Department of Human Genetics (G.P., J.C.P.), Free University Amsterdam, Amsterdam, the Netherlands; the Department of Human Genetics (P.M.S., A.W.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Neurology (M.L.), Academic Hospital Maastricht, Maastricht, the Netherlands, University of Maastricht; the Department of Human Genetics (P.L.P.), University of Utrecht, Utrecht, the Netherlands; the Department of Neurology (J.S.P.v.d.B., J.A.F.M.L.), University Hospital Nijmegen, Nijmegen, the Netherlands; and the Department of Neurology (G.J.E.R.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, the Netherlands.

Correspondence to Dr Y. Roos, Department of Neurology, Academic Medical Center (AMC), Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. E-mail y.b.roos{at}amc.uva.nl

Background and Purpose— Familial occurrence of intracranial aneurysms suggests a genetic factor in the development of these aneurysms. In this study, we present the identification of a susceptibility locus for the development of intracranial aneurysms detected by a genome-wide linkage approach in a large consanguineous pedigree.

Methods— Patients with clinical signs and symptoms of intracranial aneurysms, confirmed by radiological, surgical, or postmortem investigations, were included in the study. Magnetic resonance angiography was used to detect asymptomatic aneurysms in relatives.

Results— Seven out of 20 siblings had an intracranial aneurysm. Genome-wide multipoint linkage analysis showed a significant logarithm of the odds score of 3.55.

Conclusion— In a large consanguineous pedigree intracranial aneurysms are linked to chromosome 2p13 in a region between markers D2S2206 and D2S2977.

Key Words: genetics • intracranial aneurysm • subarachnoid hemorrhage

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