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(Stroke. 2004;35:2623.)
© 2004 American Heart Association, Inc.

Articles

Atherosclerosis of Cerebral Arteries in Alzheimer Disease

From the Longtine Center for Molecular Biology and Genetics (A.E.R., C.E., A.R.) and The W. Harold Civin Laboratory of Neuropathology (T.G.B.), Sun Health Research Institute, Sun City, Ariz; and the Department of Microbiology (T.A.K.), Midwestern University, Glendale, Ariz.

Correspondence to Dr Alex E. Roher, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, Arizona 85351. E-mail alex.roher{at}sunhealth.org

A growing body of evidence suggests that vascular disease underlies Alzheimer dementia. Atherosclerotic lesions in the circle of Willis and large leptomeningeal vessels were quantified and found to correlate with Alzheimer disease (AD) clinical diagnosis and neuropathology. We hypothesize that AD pathology is the complex end result of slowly evolving vascular disease and parenchymal lesions. Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia.

Key Words: Alzheimer disease • atherosclerosis • cerebral ischemia • circle of Willis