Donate Help Contact The AHA Sign In Home
American Heart Association
Stroke
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Stroke. 2004;35:2735-2739
Published online before print September 9, 2004, doi: 10.1161/01.STR.0000143156.32467.fd
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
35/11_suppl_1/2735    most recent
01.STR.0000143156.32467.fdv1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meschia, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meschia, J. F.
Related Collections
Right arrow Clinical genetics
Right arrow Acute Cerebral Infarction
Right arrow Cerebral Lacunes
Right arrow Genetics of Stroke

(Stroke. 2004;35:2735.)
© 2004 American Heart Association, Inc.

Articles

Clinically Translated Ischemic Stroke Genomics

James F. Meschia, MD

From the Department of Neurology, Mayo Clinic, Jacksonville, Fla.

Correspondence to Dr James F. Meschia, Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224. E-mail meschia.james{at}mayo.edu

Cohort studies show that having a positive family history of stroke increases the odds of having a stroke by {approx}30%. The heritability of stroke appears to be heterogeneous across ischemic stroke subtypes, with cardioembolic stroke being least heritable. The relative influence of stroke risk attenuates with age, but genetics does not cease to be relevant in later adulthood. Recent family history and twin studies suggest that genetic factors remain relevant even beyond the seventh decade of life. One of the challenges of gene discovery in stroke relates to the complexities of phenotype. The complexities of phenotype can be addressed by focusing on individual ischemic stroke subtypes or by studying intermediate phenotypes like leukaraiosis, which has a heritability of {approx}70%. Although most stroke genetics research has focused on the identification of risk factor genes, an independent set of genes likely influences poststroke outcomes (for example, apolipoprotein E) and response to drug therapies (example, {alpha}-adducin and diuretic therapy).


Key Words: genetics • outcome • stroke, ischemic






Stroke Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2004 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.