Published online before print January 5, 2004, doi: 10.1161/01.STR.0000109772.64650.18
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(Stroke. 2004;35:539.)
© 2004 American Heart Association, Inc.
Original Contributions |
Hemicraniectomy for Massive Middle Cerebral Artery Territory Infarction
A Systematic Review
From the Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio (R.G.), and Department of Neurological Surgery (E.S.C), Department of Neurology (S.M., M.S.V.E.), and Sergievsky Center, College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY.
Reprint requests to Dr Mitchell S.V. Elkind, Neurological Institute, 710 W 168th St, Room 641, New York, NY 10032. E-mail mse13{at}columbia.edu
Background and Purpose— Hemicraniectomy and durotomy have been proposed in many small series to relieve intracranial hypertension and tissue shifts in patients with large hemispheric infarcts, thereby preventing death from herniation. Our objective was to review the literature to identify patients most likely to benefit from hemicraniectomy.
Methods— All available individual cases from the English literature were reviewed and analyzed to determine whether age, vascular territory of infarction, side of infarction, reported time to surgery, and signs of herniation predict outcome in patients after hemicraniectomy. All studies included were retrospective and uncontrolled; there were no randomized controlled trials.
Results— Of 15 studies screened, 12 studies describing 129 patients met the criteria for analysis; 9 patients treated at our institution were added, for a total of 138 patients. After a minimum follow-up of 4 months, 10 patients (7%) were functionally independent, 48 (35%) were mildly to moderately disabled, and 80 (58%) died or were severely disabled. Of 75 patients who were >50 years of age, 80% were dead or severely disabled compared with 32% of 63 patients 
50 years of age (P<0.00001). The timing of surgery, hemisphere infarcted, presence of signs of herniation before surgery, and involvement of other vascular territories did not significantly affect outcome.
Conclusions— Age may be a crucial factor in predicting functional outcome after hemicraniectomy in patients with large middle cerebral artery territory infarction.
Key Words: craniectomy • emergency treatment • stroke • surgical treatment
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