Donate Help Contact The AHA Sign In Home
American Heart Association
Stroke
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Stroke. 2005;36:38-43
Published online before print November 29, 2004, doi: 10.1161/01.STR.0000149616.41312.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
36/1/38    most recent
01.STR.0000149616.41312.00v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Willinek, W. A.
Right arrow Articles by Urbach, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Willinek, W. A.
Right arrow Articles by Urbach, H.
Related Collections
Right arrow CT and MRI
Right arrow Carotid Stenosis
Right arrow Angiography
Right arrow Computerized tomography and Magnetic Resonance Imaging

(Stroke. 2005;36:38.)
© 2005 American Heart Association, Inc.

Original Contributions

Noninvasive Detection of Steno-Occlusive Disease of the Supra-Aortic Arteries With Three-Dimensional Contrast-Enhanced Magnetic Resonance Angiography

A Prospective, Intra-Individual Comparative Analysis With Digital Subtraction Angiography

Winfried A. Willinek, MD; Marcus von Falkenhausen, MD; Markus Born, MD; Jürgen Gieseke, PhD, MD; Tobias Höller, MSc; Thomas Klockgether, MD; Hans J. Textor, MD; Hans H. Schild, MD Horst Urbach, MD

From the Department of Radiology (W.A.W., M.v.F., M.B., J.G., H.J.T., H.H.S., H.U.), Institute of Medical Biometrics, Informatics, and Epidemiology (T.H.), and the Department of Neurology (T.K.), University of Bonn, Germany.

Correspondence to Dr W. A. Willinek, Department of Radiology, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany. E-mail winfried.willinek{at}ukb.uni-bonn.de

Background and Purpose— Concomitant disease of the supra-aortic arteries can influence the outcome of surgical treatment of carotid artery stenosis. However, sensitivity and specificity data of noninvasive contrast-enhanced 3-dimensional (3D) magnetic resonance angiography (CE MRA) for the detection of steno-occlusive disease of the entire supra-aortic arteries including the circle of Willis remain unclear. We aimed to intra-individually compare high-spatial-resolution CE 3D MRA and digital subtraction angiography (DSA) for the assessment of steno-occlusive vascular disease of the supra-aortic arteries.

Methods— CE MRA and DSA of the supra-aortic arteries were prospectively performed in 50 consecutive patients. Intra-individual comparison of CE MRA and DSA was available in 833 arteries. High-spatial-resolution CE MRA comprised a measured voxel size of 0.81 mm x 0.81 mm x 1 mm (0.66 mm3). Steno-occlusive vascular disease of the 833 arteries was assessed independently by 2 radiologists according to the NASCET criteria.

Results— CE MRA had a sensitivity of 100% (73/73), a specificity of 99.3% (760/765), a positive predictive value of 93.6% (73/78), and a negative predictive value of 100% (760/760) by using a 70% to 99% threshold of arterial diameter stenosis. For detection of occlusion, sensitivity, specificity, PPV, and NPV value of CE MRA were 100%, respectively.

Conclusions— Noninvasive high-spatial-resolution CE MRA is suited to replace diagnostic DSA for the detection of steno-occlusive disease of the supra-aortic arteries.


Key Words: carotid stenosis • comparative study • magnetic resonance angiography • magnetic resonance imaging • supra-aortic arteries




This article has been cited by other articles:


Home page
 StrokeHome page
S. M. Debrey, H. Yu, J. K. Lynch, K.-O. Lovblad, V. L. Wright, S.-J. D. Janket, and A. E. Baird
Diagnostic Accuracy of Magnetic Resonance Angiography for Internal Carotid Artery Disease: A Systematic Review and Meta-Analysis
Stroke, August 1, 2008; 39(8): 2237 - 2248.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
C. K. Kuhl, F. Traber, and H. H. Schild
Whole-Body High-Field-Strength (3.0-T) MR Imaging in Clinical Practice * Part I. Technical Considerations and Clinical Applications
Radiology, March 1, 2008; 246(3): 675 - 696.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
D. R. Hadizadeh, M. von Falkenhausen, J. Gieseke, B. Meyer, H. Urbach, R. Hoogeveen, H. H. Schild, and W. A. Willinek
Cerebral Arteriovenous Malformation: Spetzler-Martin Classification at Subsecond-Temporal-Resolution Four-dimensional MR Angiography Compared with That at DSA
Radiology, December 1, 2007; 246(1): 205 - 213.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
K. Nael, J. P. Villablanca, W. B. Pope, T. O. McNamara, G. Laub, and J. P. Finn
Supraaortic Arteries: Contrast-enhanced MR Angiography at 3.0 T--Highly Accelerated Parallel Acquisition for Improved Spatial Resolution over an Extended Field of View
Radiology, February 1, 2007; 242(2): 600 - 609.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. Huston III, M.A. Bernstein, and S.J. Riederer
Feathering: Vertebral artery pseudostenosis with elliptical centric contrast-enhanced MR angiography.
AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 850 - 852.
[Abstract] [Full Text] [PDF]


Stroke Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2005 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.