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(Stroke. 2005;36:2212.)
© 2005 American Heart Association, Inc.

Original Contributions

One-Stage Anterior Approach for Four-Vessel Occlusion in Rat

From the Department of Neurosurgery (M.Y., J.W.C., G.K., J.H.Z.), Louisiana State University Health Sciences Center, Shreveport; Division of Neurosurgery (J.H.Z.) and Department of Physiology (M.Y., J.W.C., J.H.Z.), Loma Linda University, California.

Correspondence to John H. Zhang MD, PhD, Division of Neurosurgery, Loma Linda University Medical Center, 11234 Anderson St, Room 2562B, Loma Linda, CA 92354. E-mail johnzhang3910{at}yahoo.com

Background and Purpose— We report a modified 4-vessel occlusion (4VO) rat model.

Method— We used a 1-stage anterior approach for making bilateral hemispheric ischemia.

Results— Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels.

Conclusion— This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes.

Key Words: cerebral blood flow • cerebral ischemia, global