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(Stroke. 2005;36:2654.)
© 2005 American Heart Association, Inc.

Original Contributions

Intracranial Aneurysms Treated With Endovascular Coils

Detection of Recurrences Using Unenhanced and Contrast-Enhanced Transcranial Color-Coded Duplex Sonography

Carole L. Turner, MSc; J. Nicholas P. Higgins, FRCR; Anil Gholkar, FRCR; A. David Mendelow, FRCS; Andrew J. Molyneux, FRCR; Richard S.C. Kerr, FRCS; Sanjiv Chawda, FRCR Peter J. Kirkpatrick, FRCS

From the Academic Department of Neurosurgery (C.L.T., P.J.K.), Addenbrooke’s Hospital, Cambridge, UK; Department of Neuroradiology (J.N.P.H.), Cambridge, UK; Departments of Neuroradiology (A.G.) and Neurosurgery (A.D.M.), Newcastle, UK; Departments of Neuroradiology (A.J.M.) and Neurosurgery (R.S.C.K.), Oxford, UK; and Department of Neuroradiology (S.C.), Oldchurch Hospital, Romford, UK.

Correspondence to Peter J. Kirkpatrick, FRCS, Academic Department of Neurosurgery, Box 167, Level 4, Addenbrooke’s Hospital, Hills Rd, Cambridge, CB2 2QQ, UK. E-mail pjk21{at}medschl.cam.ac.uk

Background and Purpose— Because neck recurrence after endovascular treatment of intracranial aneurysms (IAs) is not uncommon, surveillance to assess long-term stability of occlusion is clearly important. This study evaluated unenhanced and contrast-enhanced transcranial color-coded duplex sonography (TCCS) in detecting refilling of IAs treated with detachable coils.

Methods— Patients with coiled IAs were imaged before and after contrast enhancement. The results were compared with those of a surveillance digital subtraction angiogram (DSA). The operator was blinded to the results of the DSA. Aneurysms were classed as either occluded or with residual flow and quantified as minor, moderate, or extensive. There were 208 studies performed in 4 neurosurgical centers. Of those, 141 studies received ultrasonic contrast enhancement with Levovist, and 68 had an additional enhanced study with SonoVue.

Results— We excluded 44 studies. Of the 164 unenhanced studies, TCCS correctly identified 52 of 67 cases defined as completely occluded by DSA (sensitivity 78%; specificity 77%), 13 of 50 aneurysms with minor refilling (sensitivity 26%; specificity 88%), 15 of 27 aneurysms with moderate refilling (sensitivity 56%; specificity 95%), and 9 of 20 aneurysms with extensive refilling (sensitivity 45%; specificity 100%). TCCS correctly identified an additional 10 aneurysms with minor refilling after Levovist enhancement and 3 with SonoVue. Both SonoVue and Levovist enhancement identified an additional 1 aneurysm with moderate refilling and 3 with extensive refilling.

Conclusions— TCCS could be used to selectively monitor IAs, which would reduce the requirement for long-term invasive monitoring. The detection of neck refilling is improved with contrast enhancement.

Key Words: endovascular therapy • imaging techniques • intracranial aneurysm