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(Stroke. 2005;36:676.)
© 2005 American Heart Association, Inc.

Research Report

Magnetic Resonance Perfusion Tracks ¹³³Xe Cerebral Blood Flow Changes After Carotid Stenting

Nerissa U. Ko, MD; Achal S. Achrol, BSc; Alastair J. Martin, PhD; Manju Chopra, MD; David A. Saloner, PhD; Randall T. Higashida, MD William L. Young, MD

From the Departments of Neurology (N.U.K., W.L.Y.), Radiology (A.J.M., D.A.S., R.T.H.), Anesthesia and Perioperative Care (W.L.Y.), Neurological Surgery (R.T.H., W.L.Y.), and Center for Cerebrovascular Research (A.S.A., M.C., D.A.S., W.L.Y.), University of California, San Francisco; and Philips Medical Systems (A.J.M.), Cleveland, Ohio.

Correspondence to William L. Young, MD, UCSF, 1001 Potrero Ave, Room 3C-38, San Francisco, CA 94110. E-mail ccr{at}anesthesia.ucsf.edu

Background and Purpose— To compare magnetic resonance (MR) perfusion to gold-standard cerebral blood flow (CBF) determined by intra-arterial ¹³³Xe washout method.

Methods— Eight patients with high-grade carotid stenoses underwent bolus-tracking MR perfusion and intra-arterial ¹³³Xe washout before and after carotid stenting. MR perfusion was compared with ¹³³Xe-CBF values using Pearson linear correlation analysis.

Results— We observed a mean 37±38% increase in ¹³³Xe-CBF and a mean 19±27% increase in relative CBF (rCBF) by MR perfusion immediately after stent placement. Relative (percent) changes in MR-rCBF showed a close and linear correlation to those seen in ¹³³Xe-CBF (r=0.91; R²=0.84; P=0.002). There was a trend for MR perfusion to underestimate change in CBF at higher relative changes in flow.

Conclusion— Bolus-tracking MR perfusion correlates with ¹³³Xe-CBF in estimating postprocedural increases in blood flow but may underestimate the magnitude of the change with higher relative changes.

Key Words: cerebral blood flow • magnetic resonance imaging • xenon

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