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(Stroke. 2005;36:1207.)
© 2005 American Heart Association, Inc.

Original Contributions

Total Homocysteine Is Associated With White Matter Hyperintensity Volume

The Northern Manhattan Study

Clinton B. Wright, MD, MS; Myunghee C. Paik, PhD; Truman R. Brown, PhD; Sally P. Stabler, MD; Robert H. Allen, MD; Ralph L. Sacco, MD, MS Charles DeCarli, MD

From the Departments of Neurology (C.B.W., R.L.S.), Biostatistics (M.C.P), Radiology and Biomedical Engineering (T.R.B.), and the Sergievsky Center (R.L.S.), Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY; the Department of Medicine (S.P.S., R.H.A.), School of Medicine, University of Colorado, Denver, Colo; and the Department of Neurology and Center for Neuroscience (C.D.), University of California-Davis, Sacramento, Calif.

Correspondence to Dr Clinton Wright, Neurological Institute, 710 West 168th Street, New York, NY 10032. E-mail cbw7{at}columbia.edu

Background— Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations.

Methods— A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B₁₂ deficiency.

Results— Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors.

Conclusions— These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

Key Words: homocysteine • magnetic resonance imaging • white matter

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