Published online before print May 5, 2005, doi: 10.1161/01.STR.0000165920.67784.58
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Stroke. 2005;36:1298.)
© 2005 American Heart Association, Inc.
Research Reports |
HMG-CoA Reductase Inhibitors Improve Acute Ischemic Stroke Outcome
From the Department of Neurology (M.M., K.K., M.F.), University of Massachusetts Medical School, Worcester, Mass; Indevus Pharmaceuticals, Inc (U.S., B.W.S.), Lexington, Mass.
Correspondence to Majaz Moonis, Department of Neurology, University of Massachusetts Memorial Health Care, Worcester, MA 01655. E-mail moonism{at}ummhc.org
Background and Purpose— Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored.
Methods— We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score 
2 at 12 weeks and modified Rankin Scale (mRS) 2.
Results— Before stroke, 129 patients were receiving statins, 123 initiated statins within 4 weeks, and 600 patients were not on statins. Multivariate logistic regression analysis demonstrated that poststroke statins were associated with a significant probability of a favorable outcome at 12 weeks [NIHSS (P=0.002; OR, 1.92; CI, 1.27 to 2.91) and mRS (P=0.033; OR, 1.57; CI, 1.04 to 2.38)], whereas prestroke statins demonstrated a trend toward significance.
Conclusions— These preliminary results suggest that statin use may improve outcome of acute ischemic stroke.
Key Words: ischemia • stroke • stroke outcome
This article has been cited by other articles:
 |
|
 |
|
  R. H. Samson The Role of Statin Drugs in the Management of the Peripheral Vascular Patient Vascular and Endovascular Surgery, August 1, 2008; 42(4): 352 - 366. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Shimamura, N. Sato, M. Sata, H. Kurinami, D. Takeuchi, K. Wakayama, T. Hayashi, H. Iida, and R. Morishita Delayed Postischemic Treatment With Fluvastatin Improved Cognitive Impairment After Stroke in Rats Stroke, December 1, 2007; 38(12): 3251 - 3258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ovbiagele, J. L. Saver, S. Starkman, D. Kim, L. K. Ali, R. Jahan, G. R. Duckwiler, F. Vinuela, S. Pineda, and D. S. Liebeskind Statin enhancement of collateralization in acute stroke Neurology, June 12, 2007; 68(24): 2129 - 2131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Moskowitz The 2006 Thomas Willis Lecture: The Adventures of a Translational Researcher in Stroke and Migraine Stroke, May 1, 2007; 38(5): 1645 - 1651. [Full Text] [PDF]
|
|
|
|
|
|
O. Y. Bang, J. L. Saver, D. S. Liebeskind, S. Starkman, P. Villablanca, N. Salamon, B. Buck, L. Ali, L. Restrepo, F. Vinuela, et al. Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis Neurology, March 6, 2007; 68(10): 737 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-F. Li, X.-D. Pan, N. Sanossian, and B. Ovbiagele Premorbid antiplatelet use and ischemic stroke outcomes. Neurology, November 14, 2006; 67(9): 1723 - 1723. [Full Text] [PDF]
|
|
|
|
|
|
D. Deplanque, I. Masse, C. Lefebvre, C. Libersa, D. Leys, and R. Bordet Prior TIA, lipid-lowering drug use, and physical activity decrease ischemic stroke severity Neurology, October 24, 2006; 67(8): 1403 - 1410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Endres and U. Laufs Discontinuation of Statin Treatment in Stroke Patients Stroke, October 1, 2006; 37(10): 2640 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ovbiagele and M. Moonis HMG-CoA Reductase Inhibitors Improve Acute Ischemic Stroke Outcome * Response: Stroke, November 1, 2005; 36(11): 2344 - 2344. [Full Text] [PDF]
|
|