This Article Full Text Full Text (PDF) All Versions of this Article: 36/8/1735    most recent 01.STR.0000173153.51295.eev1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Verhoeven, B.A.N. Articles by Moll, F.L. Search for Related Content PubMed PubMed Citation Articles by Verhoeven, B.A.N. Articles by Moll, F.L. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Genetics Home Reference Hazardous Substances DB HEMATOXYLIN Related Collections Pathophysiology Other arteriosclerosis Carotid Stenosis Embolic stroke

(Stroke. 2005;36:1735.)
© 2005 American Heart Association, Inc.

Original Contributions

Carotid Atherosclerotic Plaque Characteristics Are Associated With Microembolization During Carotid Endarterectomy and Procedural Outcome

B.A.N. Verhoeven, MD; J.P.P.M. de Vries, MD, PhD; G. Pasterkamp, MD, PhD; R.G.A. Ackerstaff, MD, PhD; A.H. Schoneveld, Bsc; E. Velema, Bsc; D.P.V. de Kleijn, PhD F.L. Moll, MD, PhD

From the Department of Vascular Surgery (B.A.N.V., F.L.M.) and the Experimental Cardiology Laboratory (B.A.N.V., G.P., A.H.S., E.V., D.P.V.d.K.), University Medical Centre, Utrecht; the Departments of Vascular Surgery (J.P.P.M.d.V.) and Clinical Neurophysiology (R.G.A.A.) of St. Antonius Hospital, Nieuwegein; and the Interuniversity Cardiology Institute of the Netherlands (A.H.S., D.P.V.d.K.), Utrecht, the Netherlands.

Correspondence to G. Pasterkamp, Experimental Cardiology Laboratory, Heidelberglaan 100, Room G02-523, 3584 CX Utrecht, The Netherlands. E-mail g.pasterkamp{at}hli.azu.nl

Background and Purpose— During carotid endarterectomy (CEA), microemboli may occur, resulting in perioperative adverse cerebral events. The objective of the present study was to investigate the relation between atherosclerotic plaque characteristics and the occurrence of microemboli or adverse events during CEA.

Methods— Patients (n=200, 205 procedures) eligible for CEA were monitored by perioperative transcranial Doppler. The following phases were discriminated during CEA: dissection, shunting, release of the clamp, and wound closure. Each carotid plaque was stained for collagen, macrophages, smooth muscle cells, hematoxylin, and elastin. Semiquantitative analyses were performed on all stainings. Plaques were categorized into 3 groups based on overall appearance (fibrous, fibroatheromatous, or atheromatous).

Results— Fibrous plaques were associated with the occurrence of more microemboli during clamp release and wound closure compared with atheromatous plaques (P=0.04 and P=0.02, respectively). Transient ischemic attacks and minor stroke occurred in 5 of 205 (2.4%) and 6 of 205 (2.9%) patients, respectively. Adverse cerebral outcome was significantly related to the number of microembolic events during dissection (P=0.003) but not during shunting, clamp release, or wound closure. More cerebrovascular adverse events occurred in patients with atheromatous plaques (7/69) compared with patients with fibrous or fibroatheromatous plaques (4/138) (P=0.04).

Conclusions— Intraoperatively, a higher number of microemboli were associated with the presence of a fibrous but not an atheromatous plaque. However, atheromatous plaques were more prevalent in patients with subsequent immediate adverse events. In addition, specifically the number of microemboli detected during the dissection phase were related to immediate adverse events.

Key Words: carotid artery plaque • carotid endarterectomy • embolism • microcirculation • stroke