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(Stroke. 2005;36:1864.)
© 2005 American Heart Association, Inc.

Original Contributions

Impact of Hypertension and Apolipoprotein E4 on Poststroke Cognition in Subjects >75 Years of Age

E. Rowan, PhD; C.M. Morris, PhD; S. Stephens, BSc; C. Ballard, MRC Psych, MD; H. Dickinson, PhD; H. Rao, PhD; B.K. Saxby, BSc; A.T. McLaren, MRCP; R.N. Kalaria, FRC R.A. Kenny, FRCP

From the Institute for Aging and Health (E.R., C.M.M., S.S., H.R., A.T.M., R.N.K., R.A.K.), University of Newcastle upon Tyne, UK; Wolfson Centre for Age-Related Disorders (C.B.), Kings College London, UK; Centre for Health Services Research (H.D.), University of Newcastle upon Tyne, UK.; Cognitive Drug Research Ltd (B.K.S.), Goring-on-Thames, UK.

Correspondence to Elise N. Rowan, PhD, Institute for Aging and Health, Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE, UK. E-mail e.n.rowan{at}ncl.ac.uk

Background and Purpose— The apolipoprotein E4 allele (APOE4) associates with increased dementia risk, and hypertension may associate with mild cognitive deficits. We examined whether nondemented stroke patients with (1) a prestroke history of hypertension and (2) APOE4 were more cognitively impaired at 3 months after stroke.

Methods— A total of 257 participants were genotyped and outcomes from neuropsychological evaluations analyzed using regression.

Results— Total Cambridge Assessment for Mental Disorders in the Elderly (CAMCOG) and speed of working memory significantly associated with hypertension. No outcomes significantly associated with APOE4.

Conclusions— Subjects with prestroke hypertension had more impaired global cognition and slower access to information held in working memory.

Key Words: cognition • hypertension • stroke