This Article Full Text Full Text (PDF) All Versions of this Article: 37/11/2667    most recent 01.STR.0000244779.30070.1av1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sie, M. P.S. Articles by Witteman, J. C.M. Search for Related Content PubMed PubMed Citation Articles by Sie, M. P.S. Articles by Witteman, J. C.M. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Medline Plus Health Information Heart Attack Stroke Related Collections Acute myocardial infarction Acute Stroke Syndromes Genetics of Stroke Epidemiology Genetics of cardiovascular disease

(Stroke. 2006;37:2667.)
© 2006 American Heart Association, Inc.

Original Contributions

TGF-ß1 Polymorphisms and Risk of Myocardial Infarction and Stroke

The Rotterdam Study

Mark P.S. Sie, MD; André G. Uitterlinden, PhD; Michiel J. Bos, MD; Pascal P. Arp, MSc; Monique M.B Breteler, MD, PhD; Peter J. Koudstaal, MD, PhD; Huibert A.P. Pols, MD, PhD; Albert Hofman, MD, PhD; Cornelia M. van Duijn, PhD Jacqueline C.M. Witteman, PhD

From the Departments of Epidemiology and Biostatistics (M.P.S.S., A.G.U., M.J.B., M.M.B.B., H.A.P.P., A.H., C.M.v.D., J.C.M.W.), Internal Medicine (M.P.S.S., A.G.U., P.P.A., H.A.P.P.), and Neurology (M.J.B., P.J.K.), Erasmus Medical Center, Rotterdam, The Netherlands.

Correspondence to J.C.M. Witteman, PhD, Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands. E-mail j.witteman{at}erasmusmc.nl

Background and Purpose— Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cardiovascular and cerebrovascular complications. Transforming growth factor-ß1 (TGF-ß1) is a pleiotropic cytokine with a central role in inflammation. Little is known of the relation of variations within the gene and risk of cardiovascular and cerebrovascular disease. We therefore investigated 5 polymorphisms in the TGF-ß1 gene (–800 G/A, –509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study.

Methods— Participants (N=6456) of the Rotterdam Study were included in the current study. Analyses of the relations of genotypes with the risk of myocardial infarction and stroke were performed according to Cox proportional-hazards methods. All analyses were adjusted for age, sex, conventional cardiovascular risk factors, and medical history.

Results— We found no association with the risk of myocardial infarction. A significantly increased risk of stroke was found, associated with the T allele of the –509 C/T polymorphism (relative risk, 1.26; (95% CI, 1.06 to 1.49) and the Pro variant of the codon 10 polymorphism (relative risk, 1.24; 95% CI, 1.04 to 1.48).

Conclusions— No association between the TGF-ß1 polymorphisms and myocardial infarction was observed; however, the –509 C/T and codon 10 Leu/Pro polymorphisms were associated with the risk of stroke.

Key Words: myocardial infarction • polymorphisms • stroke • transforming growth factor-ß

This article has been cited by other articles:

				D. J. Grainger TGF-{beta} and atherosclerosis in man Cardiovasc Res, May 1, 2007; 74(2): 213 - 222. [Abstract] [Full Text] [PDF]