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(Stroke. 2006;37:1160.)
© 2006 American Heart Association, Inc.

Original Contributions

Alcohol Intake, Carotid Plaque, and Cognition

The Northern Manhattan Study

Clinton B. Wright, MD, MS; Mitchell S.V. Elkind, MD, MS; Tatjana Rundek, MD, PhD; Bernadette Boden-Albala, DrPh; Myunghee C. Paik, PhD Ralph L. Sacco, MD, MS

From the Division of Stroke and Critical Care (C.B.W., M.S.V.E., T.R., B.B.-A., R.L.S.), Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY; and the Departments of Biostatistics (M.C.P.) and of Epidemiology (R.L.S.), Mailman School of Public Health, Columbia University, New York, NY.

Correspondence and reprint requests to Clinton Wright, MD, MS, Division of Stroke and Critical Care, College of Physicians and Surgeons of Columbia University, NI-Room 640, 710 W168th Street, New York, NY 10032. E-mail cbw7{at}columbia.edu

Background and Purpose— Moderate alcohol intake has been associated with better cognitive performance, implicating vascular and neurodegenerative processes. Few studies to clarify the importance of vascular disease have included direct measures of atherosclerosis or minority populations at higher risk of vascular disease and dementia.

Methods— The Northern Manhattan Study includes stroke-free community based Hispanic (54%), black (25%), and white (22%) participants. We performed a cross-sectional study of alcohol intake and performance on the Mini-Mental State Examination (MMSE) in subjects with sonographic measurement of maximal carotid plaque thickness and adjusted for sociodemographic and vascular risk factors.

Results— The median MMSE score was 27 (interquartile range 24 to 29; n=2215). Reported alcohol intake was divided into 5 groups: never (n=509), past (n=494), <1 drink/week (n=300), 1/week to 2 drinks/day (n=796), and >2 drinks/day (n=116). Drinking 1 drink weekly up to 2 daily was associated with better performance on the MMSE (odds ratio=1.19; 95% CI, 1.10 to 1.26) compared with nondrinkers in women (P0.0001) but not in men, adjusting for sociodemographic and vascular risk factors. Maximal carotid plaque thickness (mean 1.1 mm; SD 1.2 mm) was not associated with alcohol intake and did not mediate the relationship between alcohol and cognition.

Conclusions— Moderate alcohol consumption was independently associated with better cognitive performance in women from this multiethnic sample. Carotid plaque was not a mediator of this association suggesting alcohol may impact cognition through a separate vascular or degenerative pathway.

Key Words: alcohol drinking • carotid artery diseases • cognition