This Article Full Text Full Text (PDF) All Versions of this Article: 37/5/1332    most recent 01.STR.0000217272.38455.a2v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baumann, C. R. Articles by Georgiadis, D. Search for Related Content PubMed PubMed Citation Articles by Baumann, C. R. Articles by Georgiadis, D. Pubmed/NCBI databases Medline Plus Health Information Stroke Related Collections Emergency treatment of Stroke Thrombolysis

(Stroke. 2006;37:1332.)
© 2006 American Heart Association, Inc.

Research Report

Good Outcomes in Ischemic Stroke Patients Treated With Intravenous Thrombolysis Despite Regressing Neurological Symptoms

Christian R. Baumann, MD; Ralf W. Baumgartner, MD; Joubin Gandjour, MD; Hans-Christian von Büdingen, MD; Adrian M. Siegel, MD Dimitrios Georgiadis, MD

From the Department of Neurology, University of Zürich, Zürich, Switzerland.

Correspondence to Dimitrios Georgiadis, MD, Department of Neurology, Universitätsspital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland. E-mail dimitrios.georgiadis{at}usz.ch

Background and Purpose— We evaluated the clinical course of 19 acute stroke patients with rapid early improvement of neurological deficit within the 3-hour window, treated with intravenous thrombolytics.

Results— No patient demonstrated a neurological deterioration during hospitalization. National Institutes of Health Stroke Scale (NIHSS) scores at therapy decision and discharge were 5 (4 to 6) and 0.5 (0 to 1.5), respectively. At 3-month follow-up, 1 patient had died; in remaining patients, NIHSS was 0 (0 to 1) and modified Rankin Scale 0.5 (0 to 1; 1 in 15 patients).

Conclusions— Withholding of intravenous thrombolysis because of spontaneous early regression of neurological symptoms may not be justified.

Key Words: cerebrovascular disorder • thrombolysis

This article has been cited by other articles:

				Thrombolytic therapy with alteplase for ischaemic stroke DTB, February 1, 2009; 47(2): 14 - 18. [Abstract] [Full Text] [PDF]

				J. De Keyser, Z. Gdovinova, M. Uyttenboogaart, P. C. Vroomen, and G. J. Luijckx Intravenous Alteplase for Stroke: Beyond the Guidelines and in Particular Clinical Situations Stroke, September 1, 2007; 38(9): 2612 - 2618. [Abstract] [Full Text] [PDF]

				K. Nedeltchev, B. Schwegler, T. Haefeli, C. Brekenfeld, J. Gralla, U. Fischer, M. Arnold, L. Remonda, G. Schroth, and H. P. Mattle Outcome of Stroke With Mild or Rapidly Improving Symptoms Stroke, September 1, 2007; 38(9): 2531 - 2535. [Abstract] [Full Text] [PDF]

				A. Aleu, P. Mellado, C. Lichy, M. Kohrmann, and P. D. Schellinger Hemorrhagic Complications After Off-Label Thrombolysis for Ischemic Stroke Stroke, February 1, 2007; 38(2): 417 - 422. [Abstract] [Full Text] [PDF]