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(Stroke. 2006;37:2162.)
© 2006 American Heart Association, Inc.
Research Reports |
From the Division of Image Processing (I.M.A., P.J.H.d.K., B.P.F.L., J.H.C.R., R.J.v.d.G), Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands, and the Russell H. Morgan Department of Radiology and Radiological Sciences (B.A.W.), Johns Hopkins Hospital, Baltimore, Md.
Correspondence to Isabel Maria Adame, Division of Image Processing (LKEB), Department of Radiology, Leiden University Medical Center (LUMC), Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail I.M.Adame{at}lumc.nl
Background and Purpose We report the evaluation of a semiautomated method for in vivo assessment of the severity of carotid atherosclerosis with minimal user interaction that combines 3-dimensional contrast-enhanced magnetic resonance angiography (CE-MRA) and vessel wall magnetic resonance imaging (MRI).
Methods Lumen and outer-wall contours were automatically detected, and stenosis and plaque burden were estimated. The method was tested on 22 subjects (352 postcontrast, T1-weighted cross sections and 3-dimensional CE-MRA).
Results We observed good correlation with expert contours: lumen and outer-wall area (r=0.96) and the degree of stenosis (r=0.97).
Conclusions The fusion of MRA and MRI reduces user interaction and improves contour detection, providing reproducible parameters to assess the severity of atherosclerosis.
Key Words: atherosclerosis carotid artery magnetic resonance angiography magnetic resonance imaging
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