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(Stroke. 2006;37:2168.)
© 2006 American Heart Association, Inc.

Case Reports

Intravenous Recombinant Tissue Plasminogen Activator in a Pregnant Woman With Cardioembolic Stroke

From the Department of Neurology (K.M.W., A.T.), University of Illinois at Peoria; and the OSF Stroke Center and Network (M.M., D.W.), Illinois Neurological Institute, OSF St. Francis Medical Center, Peoria, Ill.

Correspondence to Kathleen M. Wiese, DO, University of Illinois at Peoria, OSF St. Francis Medical Center, Department of Neurology, 530 NE Glen Oak Ave, Peoria, IL 61637. E-mail kathleenwiese{at}yahoo.com

Abstract

Background and Purpose— Historically, the use of tissue plasminogen activator (tPA) thrombolysis in pregnancy has been regarded as relatively contraindicated. Underlying this stance has been the concern over the risk of bleeding complications in both mother and child.

Summary of Case— We report the successful use of intravenous recombinant tPA (rtPA) thrombolysis in a pregnant woman with acute cardioembolic stroke.

Conclusions— The patient improved clinically, did not develop complications after receiving rtPA, and at 37 weeks’ gestation, delivered a healthy infant, demonstrating that rtPA thrombolysis may be used safely in pregnant women.

Key Words: thrombolysis • tissue plasminogen activator

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