Donate Help Contact The AHA Sign In Home
American Heart Association
Stroke
Search: search_blue_button Advanced Search
Stroke. 2007;38:192-193
Published online before print November 16, 2006, doi: 10.1161/01.STR.0000251788.03914.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
38/1/192    most recent
01.STR.0000251788.03914.00v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, K.-Y.
Right arrow Articles by Heo, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, K.-Y.
Right arrow Articles by Heo, J. H.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Stroke
Related Collections
Right arrow Acute Cerebral Infarction
Right arrow Thrombolysis

(Stroke. 2007;38:192.)
© 2007 American Heart Association, Inc.


Research Reports

Early Recanalization After Intravenous Administration of Recombinant Tissue Plasminogen Activator as Assessed by Pre- and Post-Thrombolytic Angiography in Acute Ischemic Stroke Patients

Kyung-Yul Lee, MD, PhD; Sang Won Han, MD; Seo Hyun Kim, MD; Hyo Seok Nam, MD; Sung Whan Ahn, MD; Dong Joon Kim, MD; Sang Hyun Seo, MD; Dong Ik Kim, MD Ji Hoe Heo, MD, PhD

From the Department of Neurology, National Core Research Center for Nanomedical Technology (K.-Y.L., S.W.H., S.H.K., H.S.N., S.W.A., J.H.H.) and Diagnostic Radiology (D.J.K., D.I.K., S.H.S.), Yonsei University College of Medicine, Seoul, Korea.

Correspondence to Ji Hoe Heo, MD, PhD, Department of Neurology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemoon-ku, 120-752, Seoul, Korea. E-mail jhheo{at}yumc.yonsei.ac.kr

Background and Purpose— Recanalization rates after the intravenous (IV) recombinant tissue plasminogen activator (rt-PA) treatment have been poorly studied in acute stroke.

Methods— CT angiography was performed before IV rt-PA in all patients and digital subtraction angiography was undertaken for intra-arterial thrombolysis in cases of no improvement after rt-PA infusion.

Results— Forty-five patients were treated with IV rt-PA. Initial CT angiography showed relevant arterial occlusions in 35 patients. Recanalization after rt-PA therapy was demonstrated by digital subtraction angiography in 7 of the 31 patients with the occlusion on initial CT angiography: 2/16 in the internal carotid or proximal middle cerebral artery, 3/11 in the distal middle cerebral artery and 2/4 in the basilar artery occlusion.

Conclusions— The early recanalization rate after IV rt-PA use was very low in cases with large proximal arterial occlusions. CT angiography before IV rt-PA may be useful for the prediction of its efficacy.


Key Words: CT angiography • thrombolysis • tissue plasminogen activator




This article has been cited by other articles:


Home page
RadiologyHome page
W. A. Copen, L. Rezai Gharai, E. R. Barak, L. H. Schwamm, O. Wu, S. Kamalian, R. G. Gonzalez, and P. W. Schaefer
Existence of the Diffusion-Perfusion Mismatch within 24 Hours after Onset of Acute Stroke: Dependence on Proximal Arterial Occlusion
Radiology, March 1, 2009; 250(3): 878 - 886.
[Abstract] [Full Text] [PDF]


Home page
StrokeHome page
V. Puetz, I. Dzialowski, S. B. Coutts, M. D. Hill, A. Krol, C. O'Reilly, M. Goyal, A. M. Demchuk, and for the Calgary CTA Study Group
Frequency and Clinical Course of Stroke and Transient Ischemic Attack Patients With Intracranial Nonocclusive Thrombus on Computed Tomographic Angiography
Stroke, January 1, 2009; 40(1): 193 - 199.
[Abstract] [Full Text] [PDF]


Home page
RadiologyHome page
M. P. Marks, J.-M. Olivot, S. Kemp, M. G. Lansberg, R. Bammer, L. R. Wechsler, G. W. Albers, and V. Thijs
Patients with Acute Stroke Treated with Intravenous tPA 3-6 Hours after Stroke Onset: Correlations between MR Angiography Findings and Perfusion- and Diffusion-weighted Imaging in the DEFUSE Study
Radiology, November 1, 2008; 249(2): 614 - 623.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
E.Y. Kim, E. Yoo, H.Y. Choi, J.W. Lee, and J.H. Heo
Thrombus Volume Comparison between Patients with and without Hyperattenuated Artery Sign on CT
AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 359 - 362.
[Abstract] [Full Text] [PDF]