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(Stroke. 2007;38:2851.)
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Research Letters

Magnetic Resonance Spectroscopy Study of Oxygen Therapy in Ischemic Stroke

Aneesh B. Singhal, MD; Eva Ratai, PhD; Thomas Benner, PhD; Mark Vangel, PhD; Vallent Lee, BA; Walter J. Koroshetz, MD; Pamela W. Schaefer, MD; A. Gregory Sorensen, MD R. Gilberto Gonzalez, MD, PhD

From the Departments of Neurology (A.B.S., W.J.K.) and Radiology (E.R., T.B., M.V., V.L., P.W.S., A.G.S., R.G.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass.

Correspondence to Aneesh B. Singhal, MD, J. Philip Kistler MGH Stroke Research Center, 175 Cambridge St, Suite 300, Massachusetts General Hospital, Boston, MA 02114. E-mail asinghal{at}partners.org

Abstract

Background and Purpose— Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke.

Methods— We performed multivoxel magnetic resonance spectroscopic imaging and diffusion/perfusion MRI in patients with stroke treated with NBO or room air. Imaging was performed before, during, and after therapy.

Results— Voxel-based analysis showed excellent correlation between apparent diffusion coefficient values, lactate, and N-acetyl-aspartate levels at all time points. Lactate decreased during NBO and increased post-NBO. N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients.

Conclusion— These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain.

Key Words: diffusion-weighted magnetic resonance imaging • neuroprotection • oxygen therapy • proton magnetic resonance spectroscopic imaging • stroke

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