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(Stroke. 2007;38:405.)
© 2007 American Heart Association, Inc.

Research Reports

Spontaneous and Endothelial-Independent Vasodilation Are Impaired in Patients With Spontaneous Carotid Dissection

A Case-Control Study

Ralf W. Baumgartner, MD; Barbara Lienhardt, MD; Maria Mosso, MD; Joubin Gandjour, MD; Nicolaus Michael, MD Dimitrios Georgiadis, MD

From Department of Neurology, University Hospital Zürich, Switzerland.

Correspondence to Ralf W. Baumgartner, Neurological Department, Frauenklinikstrasse 26, CH-8091 Zürich, Switzerland. E-mail ralf.baumgartner{at}usz.ch

Background and Purpose— We undertook this case-control study in patients with unilateral spontaneous dissection of the cervical internal carotid artery to investigate spontaneous and endothelium-independent dilation of the nondissected, contralateral carotid arteries and the ipsilateral brachial artery using high-resolution ultrasound.

Methods— Spontaneous and endothelial-independent (nitroglycerin-mediated) absolute and relative dilation were assessed in the internal and common carotid and brachial arteries of 27 patients with unilateral spontaneous dissection of the cervical internal carotid artery and 27 age- and sex-matched healthy controls.

Results— Absolute and relative spontaneous and endothelial-independent dilation of the carotid, but not brachial arteries, were significantly lower in patients as compared with controls.

Conclusions— Vasodilation abnormalities may be a predisposing factor for spontaneous dissection of the cervical internal carotid artery.

Key Words: arteries • nitroglycerin • ultrasonics

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