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(Stroke. 2007;38:759.)
© 2007 American Heart Association, Inc.

Intracerebral Hemorrhage: Introduction

Brain Injury After Intracerebral Hemorrhage

The Role of Thrombin and Iron

Ya Hua, MD; Richard F. Keep, PhD; Julian T. Hoff, MD Guohua Xi, MD

From the Department of Neurosurgery, University of Michigan, Ann Arbor.

Correspondence and reprint requests to Guohua Xi, MD, R5018 Biomedical Science Research Bldg, University of Michigan, 109 Zina Pitcher Pl, Ann Arbor, MI 48109-2200. E-mail guohuaxi{at}umich.edu

Abstract

Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury.

Key Words: brain edema • cerebral hemorrhage • iron • thrombin

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