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(Stroke. 2007;38:794.)
© 2007 American Heart Association, Inc.

New Approaches to Clinical Trials in Neuroprotection: Introduction

Induced Hypothermia for Acute Stroke

Thomas M. Hemmen, MD, PhD Patrick D. Lyden, MD

From the Department of Neuroscience, University of California, San Diego (T.M.F., P.D.L.), and Department of Veterans’ Affairs, San Diego, Calif (P.D.L.).

Correspondence to Thomas M. Hemmen, MD, PhD, Department of Neuroscience, University of California, San Diego, 200 W Arbor Dr, MC 8466, OPC 3rd Floor, Suite 3, San Diego, CA 92103-8466. E-mail themmen{at}ucsd.edu

Abstract

Induced hypothermia is one of the most promising neuroprotective therapies. Technological limitations and homeostatic mechanisms that maintain core body temperature have impeded the clinical use of hypothermia. Recent advances in intravascular cooling catheters and successful trials of hypothermia for cardiac arrest and neonatal asphyxia renewed interest in hypothermia for stroke, resulting in early phase clinical trials and plans for further development. This review elaborates on the clinical implications of hypothermia research in stroke and technical and logistical issues associated with the application of hypothermia.

Key Words: acute care • hypothermia • neuroprotection

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