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(Stroke. 2007;38:804.)
© 2007 American Heart Association, Inc.

New Approaches to Clinical Trials in Neuroprotection: Introduction

Nonconventional Clinical Trial Designs

Approaches to Provide More Precise Estimates of Treatment Effects With a Smaller Sample Size, but at a Cost

George Howard, DrPH

From the Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL.

Correspondence to George Howard, DrPH, Professor and Chair, Department of Biostatistics, University of Alabama at Birmingham School of Public Health, 1665 University Blvd, Birmingham, AL 35294-0022. E-mail ghoward{at}uab.edu

Abstract

Statistical sciences have recently made advancements that allow improved precision or reduced sample size in clinical research studies. Herein, we review 4 of the more promising: (1) improvements in approaches for dose selection trials, (2) approaches for sample size adjustment, (3) selection of study end point and associated statistical methods, and (4) frequentist versus Bayesian statistical methods. Whereas each of these holds the opportunity for more efficient trials, each are associated with the need for more stringent assumptions or increased complexity in the interpretation of results. The opportunities for these promising approaches, and their associated "costs," are reviewed.

Key Words: adaptive trial design • Bayesian statistics • clinical trials • frequentist statistics