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(Stroke. 2007;38:817.)
© 2007 American Heart Association, Inc.

Stem Cells and Stroke Recovery: Introduction

Cell Transplantation Therapy for Stroke

Tonya Bliss, PhD; Raphael Guzman, MD; Marcel Daadi, PhD Gary K. Steinberg, MD, PhD

From the Department of Neurosurgery (T.B., R.G., M.D., G.K.S.) and Stanford Stroke Center (G.K.S.), Stanford University, Stanford, Calif.

Correspondence to Dr G.K. Steinberg, Department of Neurosurgery, R281, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305. E-mail cerebral{at}stanford.edu

Abstract

No treatment currently exists to restore lost neurological function after stroke. A growing number of studies highlight the potential of stem cell transplantation as a novel therapeutic approach for stroke. In this review we summarize these studies, discuss potential mechanisms of action of the transplanted cells, and emphasize the need to determine parameters that are critical for transplantation success.

Key Words: clinical trials • neural stem/progenitor cells • stroke • transplantation parameters

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