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(Stroke. 2007;38:1465.)
© 2007 American Heart Association, Inc.

Original Contributions

Asymmetric Dynamic Cerebral Autoregulatory Response to Cyclic Stimuli

Rune Aaslid, PhD; Martin Blaha, MD; Gill Sviri, MD; Colleen M. Douville, BA, RVT David W. Newell, MD

From the Department of Neurological Surgery, University of Washington School of Medicine, University of Washington Medical Center, Harborview Medical Center, Seattle, Wash.

Correspondence to David W. Newell, MD, Seattle Neuroscience Institute, 550 17th Ave, Suite 500, Seattle, WA 98122. E-mail david.newell{at}swedish.org

Background and Purpose— Dynamic cerebral autoregulation has been shown to be fast and effective, but it is not well known if the mechanism is symmetric, that is to say, it acts with equal compensatory action to upward as compared with downward abrupt changes in arterial blood pressure (ABP).

Methods— Fourteen patients with head injuries and 10 normal subjects had bilateral transcranial Doppler and continuous ABP recording. Cyclic ABP stimuli were generated by large thigh cuffs, which were rapidly inflated above systolic pressure for 15 seconds alternating with 15 seconds of deflation. At least 8 such cycles were ensemble-averaged and the dynamic autoregulatory gain (AG_up and AG_dn) was estimated separately for upward and downward changes in ABP. The results were compared with the autoregulation index using conventional leg cuff releases.

Results— In normal subjects, AG_dn was 0.74±0.18 and AG_up was 0.77±0.17 (mean±SD); the difference was insignificant. The correlation between AG_dn and AG_up, however, was weak (r=0.24). In the patients with head injury, AG_dn was 0.30±0.21 and AG_up was 1.27±0.76, the difference being highly significant (P<0.001). There was a negative relationship between AG_dn and AG_up (r=–0.33). Autoregulation index correlated well with AG_dn (r=0.79) and weakly negatively with AG_up (r=–0.47).

Conclusions— A strongly asymmetric dynamic response of the cerebral autoregulation was seen the majority of patients with head injury. It might also have been present, albeit to a lesser degree, in the normal subjects. The findings suggest that nonlinear effects may be present in the operation of the cerebral autoregulation mechanism.

Key Words: cerebral autoregulation • head injury • transcranial Doppler