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Stroke. 2008;39:234-236
Published online before print November 29, 2007, doi: 10.1161/STROKEAHA.107.493767
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(Stroke. 2008;39:234.)
© 2008 American Heart Association, Inc.

Research Letters

Change in Hemostatic Markers After Recombinant Tissue-Type Plasminogen Activator Is Not Associated With the Chance of Recanalization

Joan Martí-Fàbregas, PhD; Montserrat Borrell, PhD; Dolores Cocho, MD; Sergi Martínez-Ramírez, MD; Mercè Martínez-Corral, MD; Jordi Fontcuberta, PhD Josep-Lluis Martí-Vilalta, PhD

From the Departments of Neurology (J.M.-F., D.C., S.M.-R., M.M.-C., J.-L.M.-V.) and Hematology (M.B., J.F.), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Correspondence to Joan Martí-Fàbregas, PhD, Servei de Neurologia, Hospital de la Santa Creu i Sant Pau, Av. Sant Antoni M. Claret, 167, 08025 Barcelona, Spain. E-mail jmarti{at}santpau.es

Abstract

Background and Purpose— We evaluated the association between recombinant tissue-type plasminogen activator recanalization and change in hemostatic markers.

Methods— We studied 40 patients. Recanalization was measured with transcranial Doppler. We evaluated the change in markers of coagulation (fibrinogen) and fibrinolysis (thrombin activatable fibrinolysis inhibitor and {alpha}2-antiplasmin) in patients with ischemic stroke treated with recombinant tissue-type plasminogen activator. Samples were obtained before and 90 minutes after recombinant tissue-type plasminogen activator infusion.

Results— The analyses (2-way analysis of variance) showed that the change in the value of each marker did not depend on the vascular patency status.

Conclusion— From a practical point of view, the measurement of these hemostatic markers is probably not useful for predicting recanalization.


Key Words: cerebral ischemia • hemostasis • recanalization • reperfusion • thrombolysis






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