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(Stroke. 2008;39:2943.)
© 2008 American Heart Association, Inc.

Original Contributions

Homocysteine and Its Relationship to Stroke Subtypes in a UK Black Population

The South London Ethnicity and Stroke Study

Usman Khan, MRCP; Carollyn Crossley, BSc; Lalit Kalra, PhD; Anthony Rudd, FRCP; Charles D.A. Wolfe, FFPHM; Paul Collinson, FRCPath Hugh S. Markus, FRCP

From the Centre for Clinical Neuroscience (U.K., H.S.M.), St George’s University of London, the Department of Clinical Biochemistry (C.C., P.C.), St. George’s Healthcare NHS Trust, the Department of Stroke Medicine (L.K.), King’s College London School of Medicine, Guy’s and St Thomas’ NHS Trust (A.R.), London, and the Department of Public Health Sciences (C.D.A.W.), Division of Health and Social Care Research, King’s College London, UK.

Correspondence to Professor Hugh Markus, Centre for Clinical Neuroscience, St. George’s University of London, London, SW17 0RE. E-mail hmarkus{at}sgul.ac.uk

Background and Purpose— Homocysteine is an endothelial toxin and elevated levels have been associated with stroke risk. Stroke, particularly the small vessel disease (SVD) subtype, is increased in U.S. and UK black populations. In white populations elevated homocysteine has been associated with SVD, especially confluent leukoaraiosis, and may be acting through endothelial dysfunction. We determined the association between homocysteine and stroke subtypes, especially SVD, in a well-phenotyped UK cohort of black stroke patients compared to community controls.

Methods— Homocysteine, vitamin B12, folate levels, and renal function were measured in 457 black stroke patients recruited consecutively through the prospective South London Ethnicity and Stroke Study and 179 black community controls. All patients were subtyped using modified TOAST criteria. Leukoaraiosis in SVD patients was graded according to severity, and patients were additionally categorized on the basis of presence or absence of confluent leukoaraiosis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.

Results— The highest homocysteine levels were seen in SVD patients compared to controls (16.2 [11.6] versus 11.8 [5.7] µmol/L, P<0.001) after adjusting for age, gender, vascular risk factors, vitamin levels, and renal function. Within SVD cases, highest homocysteine levels were found in lacunar infarction with confluent leukoaraiosis (19.6 [14.9] µmol/L) compared to lacunar infarction without leukoaraiosis (13.6 [7.1] µmol/L, P=0.001) and controls (P<0.001). Homocysteine correlated with leukoaraiosis severity (r=0.225, P<0.001).

Conclusions— In this well characterized UK black stroke population homocysteine levels were elevated and highest levels were found in lacunar stroke with leukoaraiosis.

Key Words: stroke • homocysteine • leukoaraiosis