This Article Full Text Full Text (PDF) All Versions of this Article: 39/3/899    most recent STROKEAHA.107.496372v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Standhardt, H. Articles by Bavinzski, G. Search for Related Content PubMed PubMed Citation Articles by Standhardt, H. Articles by Bavinzski, G. Pubmed/NCBI databases Medline Plus Health Information Brain Aneurysm Related Collections Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Angiography Aneurysm, AVM, hematoma Related Article

(Stroke. 2008;39:899.)
© 2008 American Heart Association, Inc.

Original Contributions

Endovascular Treatment of Unruptured Intracranial Aneurysms With Guglielmi Detachable Coils

Short- and Long-Term Results of a Single-Centre Series

Harald Standhardt, MD, PhD; Hans Boecher-Schwarz, MD; Andreas Gruber, MD; Thomas Benesch, PhD; Engelbert Knosp, MD Gerhard Bavinzski, MD

From the Department of Neurosurgery (H.S., H.B.-S., A.G., E.K., G.B.) and the Core Unit for Medical Statistics and Informatics, Section of Medical Statistics (T.B.), Medical University of Vienna, Austria.

Correspondence to Harald Standhardt, MD, PhD, Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. E-mail harald.standhardt{at}meduniwien.ac.at

Background and Purpose— Purpose of the present study is to evaluate the clinical outcome of endovascular treatment of unruptured intracranial aneurysms and to address the question of long-term stability and protection against future subarachnoid hemorrhage.

Methods— Retrospective analysis of all patients treated in a 12-year period (173 patients: age 26 to 76 yr, mean 52.2±10.8/202 aneurysms: size 3 to 50 mm, mean 10.0±8.3).

Results— The mortality was 0.5%; the overall morbidity was 3.5%. The most frequent complications were thromboembolic events (10.9%). Of these, 3.0% of patients suffered a stroke, leading to severe disability in 1 patient (0.5%). In 1 patient, the aneurysm ruptured during treatment, resulting in relevant neurological disability. Another patient suffered a fatal aneurysm rupture hours after treatment. The occlusion rate depended on aneurysm and neck size. Follow-up angiography revealed a decrease of the occlusion rate over time. This trend was obvious in all size categories and was most pronounced in giant aneurysms. In 3 patients (1.5%) with partially thrombosed giant aneurysms of the posterior circulation, embolization could not prevent later aneurysm rupture. There were no ruptures of any other aneurysms in the follow-up period (3.7±3.4 yr).

Conclusion— Endovascular treatment is a highly safe procedure with low intervention-related morbidity and mortality. Long-term data for nongiant aneurysms showed good protection against rupture in the observation period. In contrast, the risk of rupture for giant aneurysms of the posterior circulation was as high as expected in observational studies.

Key Words: intracranial aneurysm • endovascular treatment • outcome • subarachnoid hemorrhage

Related Article:

Management of Unruptured Intracranial Aneurysms: Perspectives on Endosaccular Coiling and Persistent Uncertainties

David G. Piepgras and Robert D. Brown, Jr
Stroke 2008 39: 743-744. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				T. Kau, J. Gasser, S. Celedin, E. Rabitsch, W. Eicher, E. Uhl, and K.A. Hausegger MR Angiographic Follow-Up of Intracranial Aneurysms Treated with Detachable Coils: Evaluation of a Blood-Pool Contrast Medium AJNR Am. J. Neuroradiol., September 1, 2009; 30(8): 1524 - 1530. [Abstract] [Full Text] [PDF]

				S. P. Ferns, M. E.S. Sprengers, W. J. van Rooij, G. J.E. Rinkel, J. C. van Rijn, S. Bipat, M. Sluzewski, and C. B.L.M. Majoie Coiling of Intracranial Aneurysms: A Systematic Review on Initial Occlusion and Reopening and Retreatment Rates Stroke, August 1, 2009; 40(8): e523 - e529. [Abstract] [Full Text] [PDF]

				D. G. Piepgras and R. D. Brown Jr Management of Unruptured Intracranial Aneurysms: Perspectives on Endosaccular Coiling and Persistent Uncertainties Stroke, March 1, 2008; 39(3): 743 - 744. [Full Text] [PDF]