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(Stroke. 2008;39:1491.)
© 2008 American Heart Association, Inc.

Original Contributions

Intra-arterial Thrombolysis of Acute Iatrogenic Intracranial Arterial Occlusion Attributable to Neuroendovascular Procedures or Coronary Angiography

Marcel Arnold, MD; Urs Fischer, MD; Gerhard Schroth, MD; Krassen Nedeltchev, MD; Joerg Isenegger, MD; Luca Remonda, MD; Stephan Windecker, MD; Caspar Brekenfeld, MD Heinrich P. Mattle, MD

From Departments of Neurology (M.A., U.F., K.N., H.P.M.), Diagnostic and Interventional Neuroradiology (G.S., L.R., C.B.), Internal Medicine (J.I.), and Cardiology (S.W.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland.

Correspondence to Caspar Brekenfeld, MD, Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Berne, Freiburgstrasse, 3010 Berne, Switzerland. E-mail caspar.brekenfeld{at}insel.ch

Background and Purpose— For selected stroke patients, intra-arterial thrombolysis (IAT) has been shown to be an effective treatment option. However, knowledge of safety and efficacy of IAT in patients with acute stroke as a complication of arterial catheter interventions is limited.

Methods— We analyzed clinical radiological findings and functional outcomes in consecutive patients 3 months after treatment with IAT for peri-procedural strokes occurring during neuroendovascular or cardiac catheter interventions. To measure outcome, the modified Rankin scale score was used.

Results— Of a total of 432 patients treated with IAT, 12 (4 women and 8 men; mean age, 60 years) were treated because of an ischemic stroke after a neuro-endovascular procedure (n=6) or coronary angiography (n=6). The median baseline National Institutes of Health Stroke Scale score was15. Recanalization was complete (thrombolysis in myocardial infarction grade 3) in 6, partial (thrombolysis in myocardial infarction 2) in 5, and minimal (thrombolysis in myocardial infarction 1) in 1. Nine patients (75%) had a favorable outcome (modified Rankin scale score, 0 to 2), and 3 had a poor outcome (modified Rankin scale score, 3 or 4). All patients with complete recanalization had a favorable outcome, whereas only 3 of 6 patients with partial or minimal recanalization (P=0.18) had a favorable outcome. Follow-up brain imaging was normal in 2 and showed new ischemic lesions in 10 patients. Two patients (17%) had a symptomatic intracerebral hemorrhage.

Conclusion— In acute stroke attributable to arterial catheter interventions, IAT is feasible and has the potential to improve outcome in these patients. A high recanalization rate could be achieved.

Key Words: angiography • outcome • thrombolysis • urokinase

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