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(Stroke. 2008;39:2382.)
© 2008 American Heart Association, Inc.

Research Letters

MRI-Based Separation of Congenital and Acquired Vertebrobasilar Artery Anomalies in Ischemic Stroke of the Posterior Circulation

Wolfgang Freund, MD; Jan Kassubek, MD; Andrik J. Aschoff, MD Roman Huber, MD

From the Department of Diagnostic and Interventional Radiology (W.F., A.J.A.), University Hospitals, Ulm, Germany; and the Department of Neurology (J.K., R.H.), University of Ulm, Germany.

Correspondence to Wolfgang Freund, Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, SteinhövelstraBe 9, 89077 Ulm, Germany. E-mail freund-ulm{at}t-online.de

Background and Purpose— Stroke MRI protocols provide useful information about underlying vessel pathologies in the anterior circulation by means of intracranial time-of-flight angiography. However, these protocols mostly fail in the posterior circulation to differentiate between congenital variants and secondary thrombosis. Therefore, a high-resolution anatomic True Fast Imaging in Steady State Precession sequence, added to a commonly used stroke imaging protocol, was evaluated.

Methods— MRIs of all emergency admissions to the stroke unit over 2 months were analyzed. Variations in the posterior circulation as displayed by time-of-flight and by the True Fast Imaging in Steady State Precession sequence, respectively, were graded by 2 readers blinded to the diagnosis.

Results— In the time-of-flight angiography, 50% of patients presented with distinctive vertebrobasilar alterations. Half of these were judged as high-grade anomalies, of which the True Fast Imaging in Steady State Precession sequence identified 25% as hypoplasia. In 40% of all patients with posterior ischemia, the True Fast Imaging in Steady State Precession sequence confirmed an acquired occlusion of the vertebrobasilar arteries.

Conclusions— The addition of an anatomic (True Fast Imaging in Steady State Precession) to a functional sequence (time-of-flight) in stroke MRI protocols enables the differentiation between artery occlusions and hypoplastic variants of the vertebral arteries.

Key Words: anatomy • clinical neurology • imaging • MRI • vertebrobasilary disease