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(Stroke. 1973;4:390.)
© 1973 American Heart Association, Inc.

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The Effects of Arterial Blood Pressure on the Regional Cerebral Blood Volume by X-Ray Fluorescence

ROBERT L. GRUBB JR. M.D.¹; MICHAEL E. PHELPS PH.D.²; MARCUS E. RAICHLE M.D.³; MICHEL M. TER-POGOSSIAN PH.D.²

¹ Division of Neurosurgery, Washington University School of Medicine, 510 South Kingshighway, St. Louis, Missouri 63110
² Division of Radiation Physics, The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway, St. Louis, Missouri 63110
³ Division of Neurology, Washington University School of Medicine, 510 South Kingshighway, St. Louis, Missouri 63110

Cerebral blood flow (CBF) remains constant over a wide range of arterial blood pressure. This is thought to be accomplished by changes in the diameter, and therefore the volume, of the cerebral resistance vessels. To test this hypothesis, regional cerebral blood volume (rCBV) was measured in vivo in Rhesus monkeys over a range of mean arterial blood pressures (MABP) of 35 to 200 torr. Multiple measurements were made in each animal by the method of stimulated x-ray fluorescence. A significant linear relationship of rCBV = 6.26 (±0.47 SD) -0.015 (±0.004 SD) MABP was found. For each one torr change in the MABP, there is a change in rCBV of 0.015 cc/100 gm of brain tissue over a range of MABP of 35 to 200 torr. An additional observation of this investigation was that autoregulation of the cerebral blood flow (CBF) is perturbed for a period lasting up to 15 minutes after the intravenous injection of Renografin 76^R.

Key Words: autoregulation • contrast agents

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