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(Stroke. 1973;4:431.)
© 1973 American Heart Association, Inc.

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Clinical Grade, Regional Cerebral Blood Flow and Angiographical Spasm in the Monkey After Subarachnoid and Subdural Hemorrhage

KENNETH C. PETRUK M.D.¹; BRYCE K. A. WEIR M.D., F.R.C.S. (C)¹; MICHAEL R. MARRIOTT B.SC. (ENG)¹; THOMAS R. OVERTON PH.D.¹

¹ Divisions of Neurosurgery and Biomedical Engineering, University of Alberta, Faculty of Medicine, Edmonton, Alberta, Canada

Division of Neurosurgery

Subarachnoid and subdural hemorrhage has been induced in the anesthetized monkey by injection of fresh autogenous blood via a needle inserted through a subfrontal twist drill hole. Serial angiographical studies and regional cerebral blood flow (rCBF) determinations were carried out concurrently for three hours following hemorrhage. The changes observed were subsequently correlated with the clinical state of the animals upon reversal of anesthesia.

In general, angiographical vasospasm and a reduction in CBF occurred simultaneously. Occasionally, however, cerebral perfusion remained unaltered after SAH even though marked vasoconstriction of the intradural vessels was present. An excellent correlation between the severity of reduced perfusion and the degree of neurological deficit was found.

Note:

Medical Research Council of Canada Fellow.

Key Words: ¹³³Xenon • intra-arterial injection method • post-SAH arrhythmias • neurological assessment

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