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(Stroke. 2009;40:3191.)
© 2009 American Heart Association, Inc.

Original Contributions

Circulating Endothelial Progenitor Cells and Age-Related White Matter Changes

Glen Jickling, MD, FRCPC; Abdul Salam, MSc; Askar Mohammad, PhD; Muhammad S. Hussain, MD, FRCPC; James Scozzafava, MD, FRCPC; Abdul Majeed Nasser, MD; Thomas Jeerakathil, MD, FRCPC; Ashfaq Shuaib, MD, FRCPC, FAHA Richard Camicioli, MD, FRCPC

From the Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Canada.

Correspondence to Dr Richard Camicioli, Division of Neurology, University of Alberta, 8440-112 Street, Edmonton, Alberta, Canada T6G 2B7. E-mail rcamicio{at}ualberta.ca

Background and Purpose— The objective was to evaluate the relationship between circulating endothelial progenitor cells (EPC) and age-related white matter changes (ARWMC). Endothelial dysfunction plays a role in the development of ARWMC. EPC incorporate into sites endothelial damage and are thought to be involved in the repair of vascular risk factor induced endothelial injury. ARWMC can be evaluated using CT or MRI.

Methods— In 172 individuals, circulating EPC were defined by the surface markers CD31 and von Willebrand factor. ARWMC were rated on CT scan using the ARWMC scale and divided into 3 groups based on ARWMC scale score (ARWMC score 0 [none], score 1–10 [mild-to-moderate], score >10 [severe]). Severity of ARWMC was correlated with levels of EPC and vascular risk factors.

Results— On univariate analysis, EPC were found to be significantly lower in patients with severe ARWMC (P=0.01). ARWMC were also associated with hypertension (P<0.001), age (P<0.001), creatinine clearance (P=0.031), C-reactive protein (P<0.001), and use of angiotensin-converting enzyme or angiotensin receptor blocker (P=0.004). Multiple logistic regression analysis identified EPC level, age, hypertension, and hypertriglyceridemia as significant independent predictors of severe ARWMC.

Conclusions— Levels of circulating EPC were significantly lower in patients with severe ARWMC. Other variables significantly associated with severe ARWMC were age, hypertension, and hypertriglyceridemia. Further study is required to delineate the pathophysiological relationship between EPC, vascular risk factors, and ARWMC.

Key Words: endothelial progenitor cells • endothelium • white matter disease