Published online before print September 17, 2009, doi: 10.1161/STROKEAHA.109.556035
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(Stroke. 2009;40:3499.)
© 2009 American Heart Association, Inc.
Original Contributions |
Noninvasive Detection of Vertebral Artery Stenosis
A Comparison of Contrast-Enhanced MR Angiography, CT Angiography, and Ultrasound
From Clinical Neuroscience (S.K., H.S.M.), St George’s University of London, UK; and Neuroradiology (P.R., A.C.), Atkinson Morley Neuroscience Centre, St George’s NHS Healthcare Trust, London, UK.
Correspondence to Hugh S. Markus, FRCP, Clinical Neuroscience, St George’s University of London, Cranmer Terrace, London, SW17 0RE, UK. E-mail hmarkus{at}sgul.ac.uk
Background and Purpose— Vertebral stenosis is associated with a high risk of recurrent stroke, but noninvasive imaging techniques to identify it have lacked sensitivity. Contrast-enhanced MR angiography and CT angiography have been recently developed and appear to have better sensitivity. However, no prospective studies have compared both of these techniques with ultrasound against the gold standard of intra-arterial angiography in the same group of patients.
Methods— Forty-six patients were prospectively recruited in whom intra-arterial angiography was being performed. Contrast-enhanced MR angiography, CT angiography, and duplex ultrasound were also performed. Angiographic images were analyzed blinded to patient identity by 2 experienced neuroradiologists.
Results— Contrast-enhanced MR angiography had the highest sensitivity and specificity (Radiologist 1, 0.83 and 0.91, respectively; Radiologist 2, 0.89 and 0.87) for detecting 
50% stenosis. CT angiography had good sensitivity (Radiologist 1, 0.68; Radiologist 2, 0.58) and excellent specificity (Radiologist 1, 0.92; Radiologist 2, 0.93), whereas duplex had low sensitivity (0.44) but excellent specificity (0.95). For vertebral origin stenosis 50%, sensitivities were similar for contrast-enhanced MR angiography (Radiologist 1, 0.91; Radiologist 2, 0.82) but relatively higher for CT angiography (Radiologist 1, 0.82; Radiologist 2, 0.82) and duplex (0.67).
Conclusions— Contrast-enhanced MR angiography is the most sensitive noninvasive technique to detect vertebral artery stenosis and also has high specificity. CT angiography has good sensitivity and high specificity. In contrast, ultrasound has low sensitivity and will miss many vertebral stenoses.
Key Words: CT • diagnostic methods • MR angiography • vertebrobasilar