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(Stroke. 2009;40:e675.)
© 2009 American Heart Association, Inc.

Case Report

Neuroimaging Demonstration of Evolving Small Vessel Ischemic Injury in Cerebral Amyloid Angiopathy

From Department of Neurology and Stroke Center (R.S.M., C.S.K.), Georgetown University, Washington, DC; National Institute of Neurological Disorders and Stroke (R.S.M.), National Institutes of Health, Bethesda, Md; Stroke Center (R.S.M.), Washington Hospital Center, Washington, DC.

Correspondence to Ravi Menon, MD, Department of Neurology, Georgetown University, 4000 Reservoir Road, NW, Suite 150, Washington, DC 20007. E-mail ravi.menon{at}gunet.georgetown.edu

Background and Purpose— Cerebral amyloid angiopathy is a small to medium vasculopathy most commonly associated with symptomatic intracerebral hemorrhage and microbleeds.

Summary of Case— We present a patient with cerebral microbleeds and likely amyloid angiopathy with evolving ischemic lesions visualized on diffusion-weighted imaging.

Conclusions— This case captures with serial MRI the evolving and dynamic nature of cerebral amyloid angiopathy and particularly illustrates the subclinical, yet progressive, ischemic aspects of this vasculopathic process.

Key Words: amyloid angiopathy • cerebrovascular disease