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(Stroke. 2009;40:868.)
© 2009 American Heart Association, Inc.

Original Contributions

Outcome of Patients With Negative CT Angiography Results for Arterial Occlusion Treated With Intravenous Thrombolysis

Robert Mikulik, MD, PhD; David Goldemund, MD; Michal Reif, MD; Petr Aulicky, MD Petr Krupa, MD

From Department of Neurology (R.M., D.G., M.R., P.A.), Masaryk University, St. Anne’s University Hospital, Brno, Czech Republic; Department of Radiology (P.K.), Masaryk University, St. Anne’s University Hospital, Brno, Czech Republic.

Correspondence to Robert Mikulik, MD, PhD, Department of Neurology, Masaryk University, St. Anne’s University Hospital, Pekaská 53, 656 91, Brno, Czech Republic. E-mail mikulik{at}hotmail.com

Background and Purpose— Stroke patients without evidence of arterial occlusion may not be suitable candidates for thrombolytic therapy. In our study, we investigated the outcomes of patients with negative CT angiography results for arterial occlusion.

Methods— The study included patients treated within 3 hours after symptom onset with intravenous thrombolysis for significant neurological deficit between August 2003 and June 2007. All of the patients were documented with negative CT angiography results for arterial occlusion by independent reviews. Outcome measurements included modified Rankin score at 3 months, incidence of intracranial hemorrhage, and infarction volume on control CT. The predictors of unfavorable outcome (modified Rankin score, 2–6) were identified by multivariate logistic regression.

Results— Altogether, 173 patients received intravenous thrombolysis; of those, 138 underwent CT angiography. The CT angiography results were negative for arterial occlusion in 39 (28%) of the patients: mean age, 71±10 years; 16 (41%) female; median baseline NIHSS, 11. At 3 months, modified Rankin score of 0 to 1 was achieved in 18 (46%) of the patients; 6 (15%) died; and 3 (8%) had symptomatic parenchymal hemorrhage. The median infarct volume was 1.5 cm³. The independent predictors of unfavorable clinical outcome were higher age (OR, 1.1; 95% CI, 1.01–1.27), and baseline NIHSS >12 (OR, 18.8; 95% CI, 1.4 to 261). One patient had encephalitis diagnosed.

Conclusions— Negative baseline CT angiography is not uncommon. The risk of intracerebral hemorrhage after thrombolytic therapy for patients without evidence of arterial occlusion is similar to the risk carried in an unselected patient population. Given the prognosis, thrombolytic therapy seems justified; however, etiology other than stroke should be considered.

Key Words: CT angiography • outcome • stroke care • thrombolysis